NIMA (Never in Mitosis Gene A)- Related Kinase 9 Protéines (NEK9)

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. De plus, nous expédions NIMA (Never in Mitosis Gene A)- Related Kinase 9 Anticorps (139) et NIMA (Never in Mitosis Gene A)- Related Kinase 9 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NEK9 91754 Q8TD19
NEK9 217718 Q8K1R7
Rat NEK9 NEK9 299204  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,741.67
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HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$932.80
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Cellules d'insectes Humain GST tag 5 μg Connectez-vous pour afficher 11 to 12 Days
$516.00
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Cellules d'insectes Humain GST tag   10 μg Connectez-vous pour afficher 3 to 4 Days
$310.00
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Baculovirus infected Insect Cells Humain GST tag   5 μg Connectez-vous pour afficher 10 to 12 Days
$363.67
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NEK9 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine)

Plus protéines pour NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) partenaires d'interaction

Human NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. Eg5 localization and centrosome separation in prophase depend on the nuclear microtubule-associated protein TPX2, a pool of which localizes to the centrosomes before nuclear envelope breakdown. This localization involves the kinase Nek9, which phosphorylates TPX2 nuclear localization signal preventing its interaction with importin and nuclear import.

  2. High expression level of NEK9 is associated with recurrence in glioblastoma.

  3. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis.

  4. Recessive NEK9 mutation is associated with lethal skeletal dysplasia.

  5. Somatic Mutations in NEK9 Cause Nevus Comedonicus.

  6. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression.

  7. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization.

  8. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53.

  9. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control.

  10. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence

  11. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.

  12. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance.

  13. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.

  14. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.

  15. binds the Ran GTPase and regulates mitotic progression

  16. Activated in mitosis, and activates nek6 and nek7 kinase.

  17. mediates certain cellular processes, which are ultimately essential for interphase progression

  18. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported.

  19. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position.

Mouse (Murine) NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. NEK9 is a critical component of the replication stress response that promotes CHK1 activity, maintaining genome integrity following challenges to DNA replication.

  2. Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores.

Xenopus laevis NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle

Profil protéine NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9)

Profil protéine

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).

Gene names and symbols associated with NEK9

  • NIMA related kinase 9 (NEK9)
  • NIMA-related kinase 9 (nek9)
  • NIMA related kinase 8 (NEK8)
  • NIMA related kinase 9 (nek9)
  • NIMA (never in mitosis gene a)-related expressed kinase 9 (Nek9)
  • NIMA-related kinase 9 (Nek9)
  • NIMA-related kinase 9 L homeolog (nek9.L)
  • NIMA related kinase 9 (Nek9)
  • C130021H08Rik Protéine
  • Nek8 Protéine
  • NEK9 Protéine
  • nercc Protéine
  • nercc1 Protéine

Protein level used designations for NEK9

NIMA (never in mitosis gene a)- related kinase 9 , NIMA-related kinase Nek8 , nercc1 kinase , never in mitosis A-related kinase 9 , nimA-related kinase 8 , nimA-related protein kinase 9 , serine/threonine-protein kinase Nek9 , NIMA-related kinase 8 , serine/threonine-protein kinase Nek9-like , NIMA-family kinase Nercc1 , XNek9

GENE ID SPECIES
91754 Homo sapiens
428891 Gallus gallus
490790 Canis lupus familiaris
534652 Bos taurus
701707 Macaca mulatta
100216232 Xenopus (Silurana) tropicalis
100345106 Oryctolagus cuniculus
100461917 Pongo abelii
100474361 Ailuropoda melanoleuca
100543466 Meleagris gallopavo
100556817 Anolis carolinensis
217718 Mus musculus
299204 Rattus norvegicus
100152772 Sus scrofa
398600 Xenopus laevis
100713019 Cavia porcellus
100057328 Equus caballus
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