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NKX2-3 encodes a homeodomain-containing transcription factor. De plus, nous expédions NK2 Homeobox 3 Anticorps (16) et beaucoup plus de produits pour cette protéine.
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Studies suggest oncogenic NK2 homeobox 3 homeobox protein (NKX2-3) in lymphomagenesis, and show a mouse model for studying the biology and therapy of human marginal-zone B-cell lymphomas.
NKX2-3 is a key mediator for maintaining myofibroblast characteristics, and our results show that colorectal myofibroblasts, as defined by the expression of AOC3, NKX2-3, and other markers, are a distinctly different cell type from TGFbeta-activated fibroblasts
The persons with a NKX2-3 G or T allele may have a moderately increased risk of CD.
NKX2-3 may play different roles in ulcerative colitis and Crohn's disease pathogenesis by differential regulation of EGR1.
A positive correlation was observed between mRNA expression of PTPN2 and NKX2-3 in B cells and in intestinal tissues from both Crohn's disease and ulcerative colitis patients.
The binding of NFAT1 to the NKX2-3 promoter region with rs1190140 was confirmed by chromatin immunoprecipitation assay.
the risk haplotype of NKX2.3 confers susceptibility to UC through increasing expression of NKX2.3 mRNA in the colonic mucosa.
NKX2-3 may play an important role in inflammatory bowel disease pathogenesis by regulating endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells.
Data suggest that NKX2-3 and IRGM are susceptibility loci for inflammatory bowel disease in Eastern European patients.
Nkx2-3 may contribute to the pathogenesis of inflammatory bowel disease-associated colorectal cancer and sporadic colorectal cancer by regulating the Wnt signaling pathway.
a decrease in Nkx2-3 gene expression level can profoundly alter the expression of genes and cellular functions relevant to the pathogenesis and progression of inflammatory bowel disease, such as EDN1.
Single nucleotide polymorphism in NKX2-3 gene is associated with Crohn's disease and ulcerative colitis
A positive association signal presumably common to different ethnic groups for rs10883365 was detected in the upstream region of NKX2-3.
no evidence of association with celiac disease has been reported for the Crohn's disease susceptibility polymorphisms studied in the NKX2-3, ATG16L1, and IRGM genes.
Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.
the organ-specific patterning of splenic vasculature is critically regulated by Nkx2-3, thereby profoundly affecting the lymphocyte homing mechanism and blood filtering capacity of the spleen in a tissue-specific manner.
The splenic vascular defects in Nkx2-3 deficiency include the generation of LYVE-1(+) cysts, comprised of endothelial cells without being committed along the LEC lineage.
NKX2.3 has a role in mouse pharyngeal organogenesis
Data indicate a substantial role for Nkx2-3 in the correct association of lymphocytes and splenic stromal elements that is independent of chemokine expression.
Phenotypic heterogeneity among different vascular elements within distinct anatomical regions of the spleen differentially depends on developmental factors such as lymphotoxin signaling or Nkx2.3, whereas the marginal sinus is controlled by both pathways.
Formation of various white pulp fibroblast subsets is differentially affected by the presence of Nkx2.3 activity, possibly also influencing their role in various immune functions linked with complement activation and deposition.
This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.
NK2 transcription factor related, locus 3
, homeobox protein NK-2 homolog C
, homeobox protein Nkx-2.3
, Drosophila NK2 transcription factor related, locus 3
, homeobox protein NK-2 homolog 3