Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) Protéines (NPR1)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). De plus, nous expédions NPR1 Anticorps (100) et NPR1 Kits (25) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NPR1 4881 P16066
NPR1 24603 P18910
NPR1 18160 P18293
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Top NPR1 Protéines sur anticorps-enligne.fr

Showing 8 out of 12 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Escherichia coli (E. coli) Humain His-SUMO Tag 100 μg Connectez-vous pour afficher 11 Days
$411.40
Détails
Levure Humain His tag 100 μg Connectez-vous pour afficher 8 to 11 Days
$484.00
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$3,234.00
Détails
Baculovirus infected Insect Cells Humain GST tag   50 μg Connectez-vous pour afficher 10 to 12 Days
$624.55
Détails

NPR1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , , , ,
, , , ,
Rat (Rattus)

Mouse (Murine)
,

Plus protéines pour Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) partenaires d'interaction

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.

  2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

  3. Data suggest that signaling via ANP (Montrer NPPA Protéines)/ANPR (atrial natriuretic factor/ANP (Montrer NPPA Protéines) receptor (Montrer PPP5C Protéines)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (Montrer PAK4 Protéines)) and CCM2 (cerebral cavernous malformation 2 (Montrer CCM2 Protéines) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (Montrer NPPA Protéines)/ANPR signaling.

  4. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (Montrer NT5C2 Protéines) in HEK (Montrer EPHA3 Protéines)-293 cells.

  5. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitiv (Montrer INS Protéines)ity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.

  6. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation

  7. NPRA was detected in E11.5 cardiac progenitor cells.

  8. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

  9. High NPR1 expression is associated with esophageal squamous cell carcinomas.

  10. Molecular dynamics analysis indicated decreases in the values of Van (Montrer TNIP1 Protéines) der (Montrer GDF3 Protéines) Waals, electrostatic energy and potential energy of NPRB (Montrer NPR2 Protéines)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

Zebrafish Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. Study identified 2 versions of the npr1 gene (npr1a and npr1b); npr1a was mainly expressed in tectal ventricle, brian, heart and retina, whereas npr1b was broadly present in anterior pronephric duct. npr2 mainly expressed in branchial arches and neural tube during embryonic development; npr3 was expressed in pronephric ducts and corpuscle of stannius in zebrafish embryos at 72 hours after fertilization.

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. A decreased Npr1 copy number enhanced the expression of hypertrophic markers.

  2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

  3. KLF10 and atrial natriuretic peptide (Montrer NPPA Protéines)/NPRA in exerting influences on chronic pulmonary disease pathogenesis

  4. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase (Montrer HDAC1 Protéines) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (Montrer HDAC1 Protéines)/2, NF-kappaB (Montrer NFKB1 Protéines) (p65 (Montrer NFkBP65 Protéines)), and STAT1 (Montrer STAT1 Protéines).

  5. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  6. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

  7. Conclude that postnatal cardiac hyperplasia in mice with global GC-A (Montrer GUCA1A Protéines) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.

  8. Data (including data from studies in knockout mice) suggest expression of ANP (Montrer NPPA Protéines)/BNP/GC-A (Montrer GUCA1A Protéines) (atrial natriuretic peptide (Montrer NPPA Protéines), brain natriuretic peptide (Montrer BNP Protéines), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.

  9. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.

  10. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin (Montrer INS Protéines) sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

Arabidopsis thaliana Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

  1. This work uncovers a strategy in which Pseudomonas syringae AvrPtoB targets Arabidopsis NPR1 and represses NPR1-dependent salicylic acid signaling, thereby subverting plant innate immunity.

  2. The findings provide strong support for the direct regulatory roles of TGA3 and WRKY53 in the salicylic acid (SA) and NPR1-dependent activation of a Caulimoviral promoter (CmYLCV).

  3. the characterization of a zinc-finger protein-coding gene AtOZF1 that positively influences NPR1-independent salicylic acid signaling, is reported.

  4. study not only provides a convenient and efficient transient expression system, but also reveals that NPR1-dependent SA signaling is a major barrier to efficient transient expression

  5. We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.

  6. Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.

  7. The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.

  8. Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.

  9. The authors show that sumoylation of NPR1 by SUMO3 (Montrer SUMO3 Protéines) activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA (Montrer TBX1 Protéines) transcription activators.

  10. Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.

Profil protéine NPR1

Profil protéine

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994

Gene names and symbols associated with NPR1

  • natriuretic peptide receptor 1 (NPR1)
  • natriuretic peptide receptor 1 (Npr1)
  • natriuretic peptide receptor 1a (npr1a)
  • regulatory protein (NPR1) (NPR1)
  • AI893888 Protéine
  • ANPa Protéine
  • Anpra Protéine
  • ARABIDOPSIS NONEXPRESSER OF PR GENES 1 Protéine
  • ATNPR1 Protéine
  • F15H21.6 Protéine
  • F15H21_6 Protéine
  • GC-A Protéine
  • Gca Protéine
  • GUC2A Protéine
  • GUCY2A Protéine
  • NIM1 Protéine
  • NON-INDUCIBLE IMMUNITY 1 Protéine
  • NONEXPRESSER OF PR GENES 1 Protéine
  • NPR-A Protéine
  • Npra Protéine
  • Pndr Protéine
  • REGULATORY PROTEIN NPR1 Protéine
  • SAI1 Protéine
  • SALICYLIC ACID INSENSITIVE 1 Protéine
  • sGC Protéine
  • si:dkey-27c15.1 Protéine

Protein level used designations for NPR1

ANP-A , ANPR-A , GC-A , NPR-A , atrial natriuretic peptide receptor 1 , atrial natriuretic peptide receptor type A , atrionatriuretic peptide receptor A , guanylate cyclase A , natriuretic peptide A type receptor , natriuretic peptide receptor A , atrial natriuretic peptide A-type receptor , atrial natriuretic peptide receptor A , natriuretic peptide receptor 1 , aatriuretic peptide receptor A , guanylyl cyclase beta 1, soluable , natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) , Nppa receptor , guanylyl cyclase-A

GENE ID SPECIES
4881 Homo sapiens
24603 Rattus norvegicus
560653 Danio rerio
100343663 Oryctolagus cuniculus
18160 Mus musculus
842733 Arabidopsis thaliana
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