Neuropilin (NRP) and Tolloid (TLL)-Like 2 Protéines (NETO2)

NETO2 encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. De plus, nous expédions NETO2 Anticorps (52) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
NETO2 81831 Q8NC67
NETO2 74513 Q8BNJ6
NETO2 307757 C6K2K4
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Showing 4 out of 9 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,874.67
Détails

NETO2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,
Mouse (Murine)
,
Rat (Rattus)

Plus protéines pour Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) partenaires d'interaction

Human Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) interaction partners

  1. upregulation of NETO2 gene is first stipulated by the isoform 1 (NM_018092.4), and the probable mechanism of its activation is associated with the increased expression of SAP30 transcription factor.

  2. NETO2 may be involved in colorectal cancer progression, but is not directly associated with epithelial-mesenchymal transition

  3. Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors

  4. NETO2 upregulation could serve as a potential biomarker for the prediction of advanced tumor progression and unfavorable prognosis in patients with colorectal carcinoma.

  5. Determination of the neuropilin and tolloid-like protein 2 signal peptide cleavage site by N-terminal sequencing.

  6. Rat neto2 plays a role in glutamate signaling in the brain by modulating the function of kainate receptors.

Mouse (Murine) Neuropilin (NRP) and Tolloid (TLL)-Like 2 (NETO2) interaction partners

  1. KAR-mediated excitation of interneurons is contingent upon Neto1 because kainate yields comparable effects in Neto2 knockouts and wild-types but fails to excite interneurons or recruit inhibition in Neto1 knockouts.

  2. Pain-transducing peripheral sensory neurons of the dorsal root ganglia (DRG) express kainate receptors (KARs), a subfamily of glutamate receptors that modulate neurite outgrowth and regulate glutamate release at the DRG-dorsal horn synapse.

  3. These results establish critical roles for Neto auxiliary subunits controlling Kainate receptor properties and synaptic incorporation.

  4. Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors.

  5. Loss of the Neto2:KCC2 interaction reduced KCC2-mediated Cl(-) extrusion, resulting in decreased synaptic inhibition in hippocampal neurons.

  6. Btcl2 mRNA was observed restrictively in brain throughout embryonic and postnatal stages; expressed in the pontine nucleus and subplate, which are required for establishing the neuronal circuit formation.

Profil protéine NETO2

Profil protéine

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with NETO2

  • neuropilin and tolloid like 2 (NETO2)
  • neuropilin and tolloid like 2 (neto2)
  • neuropilin (NRP) and tolloid (TLL)-like 2 (Neto2)
  • neuropilin and tolloid like 2 (Neto2)
  • neuropilin (NRP) and tolloid (TLL)-like 2 (NETO2)
  • 5530601C23Rik Protéine
  • AI854825 Protéine
  • BTCL2 Protéine
  • MGC145990 Protéine
  • NEOT2 Protéine

Protein level used designations for NETO2

neuropilin (NRP) and tolloid (TLL)-like 2 , neuropilin- and tolloid-like protein 2 , brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 , neuropilin and tolloid-like protein 2 , neuropilin and tolloid like-2

GENE ID SPECIES
716468 Macaca mulatta
780374 Xenopus (Silurana) tropicalis
100016179 Monodelphis domestica
100550452 Meleagris gallopavo
415743 Gallus gallus
81831 Homo sapiens
74513 Mus musculus
307757 Rattus norvegicus
478142 Canis lupus familiaris
100624026 Sus scrofa
520056 Bos taurus
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