Opioid Receptor, kappa 1 Protéines (OPRK1)

a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin [RGD, Feb 2006].. De plus, nous expédions Opioid Receptor, kappa 1 Anticorps (128) et Opioid Receptor, kappa 1 Kits (7) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
OPRK1 4986 P41145
OPRK1 18387 P33534
Rat OPRK1 OPRK1 29335 P34975
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days

OPRK1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Mouse (Murine)

Plus protéines pour Opioid Receptor, kappa 1 (OPRK1) partenaires d'interaction

Zebrafish Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. ZFOR3 is a unique model to study kappa opioid receptor functionality

Rabbit Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. These findings provide evidence that previously demonstrated KOR-mediated reduction in intraocular pressure could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork.

Human Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. The OPRK1 gene variants showed significant association with susceptibility to opioid dependence among Iranians.

  2. Down-regulation of KOR in HCC (Montrer FAM126A Protéines) tumour tissues has a strong association with poor prognosis and KOR might be a potential tumour suppressor.

  3. In HUVEC cells subjected to artificial hyperlipidemia, selective agonists and antagonists showed that kappa-opioid receptor stimulation normalizes endothelial ultrastructure and function under hyperlipidemic conditions via the PI3K (Montrer PIK3CA Protéines)/Akt (Montrer AKT1 Protéines)/eNOS (Montrer NOS3 Protéines) pathway.

  4. The OPRK1/kappa-opioid receptor pathway was found to be downregulated in lesional skin of psoriasis, correlating positively with itch sensation.

  5. Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK (Montrer EPHA3 Protéines)) cells stably transfected with one of KOP (Montrer SPINT2 Protéines), MOP (Montrer NLN Protéines) or DOP (Montrer COPB2 Protéines)

  6. These results indicate that KOR can form a heterodimer with B2R (Montrer BDKRB2 Protéines) and this leads to increased protein kinase A activity by the CREB (Montrer CREB1 Protéines) signaling pathway, leading to a significant increase in cell proliferation.

  7. that promoter fragments of OPRK1 and OPRM1 (Montrer OPRM1 Protéines) were able to upregulate gene expression with mild cognitive impairment

  8. Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (Montrer ARRB2 Protéines)-signaling pathway.

  9. Hypoxia inducible factor-1alpha (HIF-1alpha (Montrer HIF1A Protéines)) siRNA knocked down the increase of endogenous HIF-1alpha (Montrer HIF1A Protéines) messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.

  10. genetic association studies in a population in Denmark: Data suggest that carriers/heterozygotes of the C allele (CC/CT) of OPRK SNP rs6473799 report a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers.

Mouse (Murine) Opioid Receptor, kappa 1 (OPRK1) interaction partners

  1. Suggest that peripheral and central MOR (Montrer OPRM1 Protéines) and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice.

  2. chronic KOR activation increased phosphorylation of NR2B (Montrer GRIN2B Protéines) subunit of NMDA at tyrosine 1472 (pNR2B NMDA) in the hippocampus, but not in the cortex.

  3. Pre- and postsynaptic colocalization of kappa opioid receptor and D2R (Montrer DRD2 Protéines) supports a role for kappa opioid receptor potentiating both the D2R (Montrer DRD2 Protéines) inhibitory autoreceptor function and the inhibitory action of D2R (Montrer DRD2 Protéines) on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R (Montrer DRD2 Protéines) sensitization by contributing to decrease dopamine release in the nucleus accumbens.

  4. Mechanical allodynia produced by monosodium iodoacetate (MIA (Montrer MIA Protéines)) was enhanced in mice lacking KOR or PDYN (Montrer PDYN Protéines) gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA (Montrer MIA Protéines) administration was similar in KOR-KO, PDYN (Montrer PDYN Protéines)-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA (Montrer MIA Protéines) administration.

  5. The kappa opioid receptor was identified as a key player mediating the effects of buprenorphine in tests sensitive to antidepressant drugs in mice.

  6. This study provides the first evidence for a time- and learning-dependent property of neocortical kappa opioid receptor in facilitating acquisition and consolidation of associative memories.

  7. triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation

  8. This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination.

  9. GRK2 (Montrer ADRBK1 Protéines) upregulation causes kappa-opioid receptor desensitization in diabetic heart

  10. Study showed that Dyn (Montrer PDYN Protéines)-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus

Profil protéine Opioid Receptor, kappa 1 (OPRK1)

Profil protéine

a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin

Gene names and symbols associated with OPRK1

  • opioid receptor, kappa 1 (oprk1)
  • opioid receptor kappa 1 (OPRK1)
  • opioid receptor, kappa 1 (Oprk1)
  • opioid receptor kappa 1 (Oprk1)
  • K-OR-1 Protéine
  • KOR Protéine
  • KOR-1 Protéine
  • LOC780448 Protéine
  • MSL-1 Protéine
  • OPRK Protéine
  • OPRK1 Protéine
  • Oprk2 Protéine
  • R21 Protéine

Protein level used designations for OPRK1

ZFOR3 , ZfKOR , kappa-type opioid receptor , opioid receptor, kappa 1 , kappa opioid receptor , K-OR-1 , KOR-1 , Opiate receptor, kappa-1 , opioid receptor, kappa 2

360139 Danio rerio
428533 Gallus gallus
486951 Canis lupus familiaris
780448 Ovis aries
100152118 Sus scrofa
100354170 Oryctolagus cuniculus
100587333 Nomascus leucogenys
4986 Homo sapiens
540519 Bos taurus
18387 Mus musculus
29335 Rattus norvegicus
100135587 Cavia porcellus
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