PHD Finger Protein 8 (PHF8) Kits ELISA

The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. De plus, nous expédions PHF8 Anticorps (38) et PHF8 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
PHF8 320595 Q80TJ7
PHF8 23133 Q9UPP1
Anti-Rat PHF8 PHF8 317425  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Souris 0.118 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
Humain 25.2 pg/mL 78.125 pg/mL - 5000 pg/mL   96 Tests 15 to 17 Days

Plus Kits ELISA pour PHF8 partenaires d'interaction

Mouse (Murine) PHD Finger Protein 8 (PHF8) interaction partners

  1. These results clarify the functional role of Phf8 in mammalian development and behavior.

  2. PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP) in the hippocampus.

  3. knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment.

  4. PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.

  5. The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation.

  6. an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate

Human PHD Finger Protein 8 (PHF8) interaction partners

  1. PHF8 knockdown generates the immunosuppressive alternative splice product soluble HLA-G, which is secreted by endothelial cells to elicit a potential inhibitory effect on inflammation

  2. these results demonstrated that PHF8 was a novel oncogene in hepatocellular carcinoma

  3. These findings suggested that PHF8 played an oncogenic role in facilitating FIP200-dependent autophagic degradation of E-cadherin, EMT and metastasis in hepatocellular carcinoma (HCC). PHF8 might be a promising target for prevention, treatment and prognostic prediction of HCC.

  4. the PHF8 oncogene is involved in the progression of CRC. The preliminary findings indicated that PHF8, as a potential target of miR-488, can be suppressed by the overexpression of miR-488. Low levels of miR-488 and high levels of PHF8 were correlated with poor overall survival rates in patients with CRC.

  5. PIP2-binding mutant of PHF8 has increased the activity of rDNA promoter (20%) and expression of pre-rRNA genes (47S-100%; 45S-66%).

  6. Our data reveal novel mechanisms that underlie the regulation of PHF8 and KDM3A during NED and in CRPC, and support the candidacy of PHF8 as a therapeutic target in CRPC.

  7. Thus, PHF8 forms a positive feedback loop with the MEK/ERK pathway, and PHF8 knockdown enhances the lethality of PD184352 in ALL cells. In conclusion, this study identifies oncogenic functions of PHF8 in adult ALL and suggests a novel epigenetic strategy for disease intervention.

  8. Knockdown or knockout of PHF8 by RNAi or CRISPR-Cas9 system reduced the activation of HIF1alpha.

  9. USP7 promotes breast carcinogenesis by stabilizing PHF8 and upregulating cyclin A2. and the interaction between USP7 and PHF8 is augmented during DNA damage.

  10. PHF8 reduces the H3K9me2 level at the E2F4 transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 gene regulation

  11. PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.

  12. PHF8 promotes lung cancer cell growth and survival by regulating miR-21.

  13. knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.

  14. PHF8 is regulated by APC(cdc20) and plays an important role in the G2/M transition.

  15. study identified the histone demethylase PHF8 as a coactivator that is specifically recruited by RAR-alpha fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia

  16. Results show that PHF8 controls the expression of genes involved in cell adhesion and cytoskeleton organization such as RhoA, Rac1 and GSK3beta.

  17. a role of PHF8 in cell migration and invasion

  18. PHF8 is a histone demethylase and coactivator for RARalpha and that the F279S mutation identified in an XLMR patient results in loss of its demethylase activity.

  19. H3K9me2 level was elevated in the promoter region of the rDNA gene in PHF8 knockdown cells and reduced significantly when the wild type but not the catalytically inactive H247A mutant PHF8 was overexpressed.

  20. PHF8 demethylates H4K20me1 and H3K9me1 both in vitro and in vivo, and both H3K4me3-binding and catalytic functions of PHF8 are important for its ability to positively regulate gene expression

Zebrafish PHD Finger Protein 8 (PHF8) interaction partners

  1. PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways

PHF8 profil antigène

Antigen Summary

The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PHD Finger Protein 8 (PHF8) Kits ELISA

  • PHD finger protein 8 (Phf8) anticorps
  • PHD finger protein 8 (PHF8) anticorps
  • PHD finger protein 8 (phf8) anticorps
  • 9830141C09Rik anticorps
  • JHDM1F anticorps
  • mKIAA1111 anticorps
  • MRXSSD anticorps
  • RGD1561065 anticorps
  • ZNF422 anticorps
  • zPHF8 anticorps

Protein level used designations for PHD Finger Protein 8 (PHF8) Kits ELISA

histone lysine demethylase PHF8 , jumonji C domain-containing histone demethylase 1F

320595 Mus musculus
23133 Homo sapiens
317425 Rattus norvegicus
491897 Canis lupus familiaris
513959 Bos taurus
100520413 Sus scrofa
566534 Danio rerio
100344764 Oryctolagus cuniculus
100060410 Equus caballus
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