Paired-Like Homeodomain 1 Protéines (PITX1)

PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. De plus, nous expédions PITX1 Anticorps (52) et PITX1 Kits (9) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PITX1 5307 P78337
PITX1 113983 Q99NA7
PITX1 18740 P70314
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
Levure Xenopus laevis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days

PITX1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
Rat (Rattus)

Mouse (Murine)

Plus protéines pour Paired-Like Homeodomain 1 (PITX1) partenaires d'interaction

Rabbit Paired-Like Homeodomain 1 (PITX1) interaction partners

  1. In the anterior segment of the posterior pitx2 expression domain, the anterior streak domain is defined by nodal expression as a hypothetical progenitor region of the anterior half of the primitive streak

Human Paired-Like Homeodomain 1 (PITX1) interaction partners

  1. Significantly higher methylation level and lower PITX1 gene expression are found in adolescent idiopathic scoliosis.

  2. PITX1 might serve as a potential biomarker for early detection and prognosis prediction of patients with lung adenocarcinoma.

  3. As a transcriptional activator, PITX1 regulates apoptosis-related genes, including PDCD5, during gastric carcinogenesis.

  4. we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in colorectal carcinoma(CRC). Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC

  5. Methylation status of PITX1 and even more so of lincRNA C5orf66-AS1 is a promising prognostic biomarker in HNSCC, in particular for HPV-negative patients. Further prospective evaluation is warranted

  6. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes

  7. Our results suggest that mutation of a specific loop both affects the global G4 structure and impacts the ability to interact with a G4 binding protein and small molecule ligand.

  8. PITX1 expression may be involved in tumor progression and is a potential tumor suppressor gene and prognostic marker for cutaneous malignant melanoma.

  9. PTP1B dephosphorylates PITX1 to weaken its protein stability and the transcriptional activity for p120RasGAP gene expression

  10. To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified. (Review)

  11. Low PITX1 expression is associated with lung metastasis in osteosarcoma.

  12. We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5.

  13. Down-regulation of PITX1 expression might contribute to the progression of cutaneous malignant melanoma via promoting cell proliferative activity

  14. PITX1 regulates HIF-1a activity by binding to HIF-1b and regulatingHIF recruitment to specific target promoters.

  15. DUX4 gene is activated in a small number of myonuclei, the DUX4 proteins diffuse to adjacent nuclei where they activate target genes such as PITX1.

  16. Lienberg syndrome results from a misexpression of PITX1 in upper extremities.

  17. A deletion in H2AFY gene and 190,428bp of its downstream region contains a regulatory sequence that suppresses the expression of PITX1 in the upper limb buds and causes Liebenberg syndrome.

  18. Identified two deletions and a translocation 5' of PITX1.

  19. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas.

  20. mutations in PITX1 can cause a broad spectrum of isolated lower-limb malformations including clubfoot, deficiency of long bones, and mirror-image polydactyly.

Mouse (Murine) Paired-Like Homeodomain 1 (PITX1) interaction partners

  1. Pitx1 is controlled by an enhancer (Pen) that shows activity in forelimbs and hindlimbs. Forelimbs and hindlimbs have fundamentally different chromatin configurations, whereby Pen and Pitx1 interact in hindlimbs and are physically separated in forelimbs. Structural variants can convert the inactive into the active conformation, thereby inducing Pitx1 misexpression in forelimbs.

  2. Pitx1 distal enhancer loss have only mild effects on Pitx1 expression in the hindlimb and no overt effects on hindlimb or mandibular morphology.

  3. data suggest that PITX1 promotes chondrogenesis and myogenesis in the hindlimb by direct regulation of several key members of the cartilage and muscle transcriptional networks.

  4. Results indicate autonomously programmed differences in forelimb and hindlimb cartilage precursors of the limb skeleton are controlled, at least in part, by Pitx1 and suggest this has an important role in generating distinct limb-type morphologies.

  5. Pitx1 targets sites that are in a similar chromatin state in Forelimbs (FLs) and hindlimbs and controls expression of patterning genes as well as the chondrogenic program.

  6. Pitx1 influences hindlimb morphology both through the activation of hindlimb-specific enhancers as well as through the hindlimb-specific modulation of enhancers that are active in both sets of limbs

  7. The results suggest that PITX2 and PITX1 have overlapping roles in thyrotroph function and response to hypothyroidism.

  8. PITX1 haploinsufficiency may cause a developmental field defect preferentially affecting the lateral lower leg.

  9. It was shown that, firstly, Pitx1 influences hindlimb outgrowth by regulating Tbx4 expression levels and that, subsequently,Pitx1 shapes hindlimb bone and soft tissue morphology independently of Tbx4.

  10. These findings provide evidence that c-Abl participates in modulating Pitx1 expression in the apoptotic response to DNA damage.

  11. Thus, Pitx1 and Pitx2 genes are required for sustained hindlimb bud growth and formation of hindlimbs

  12. expression during cardiovascular development

  13. PITX1 autoregulation depends on DNA-binding and trans-activation domains of Pitx1 and it may be responsible for establishment and/or maintenance of the Pitx1 expression domain.

  14. Results suggest that pituitary homeobox 1 (Pitx-1) can direct transactivation of the mouse gonadotropin-releasing hormone receptor gene, in part by DNA binding and in part by an action of Pitx-1 as a cofactor for AP-1

  15. Although PITX1 protein is present in expression pattern similar to PITX2 throughout pituitary development, it has less prominent role than PITX2.

  16. These results demonstrate that Pitx1, but not Tbx4, determines the morphological identity of hindlimb tissues.

  17. Deletion of the Pitx1 genomic locus affects mandibular morphogenesis and expression of the Barx1 and Tbx1 genes.

Xenopus laevis Paired-Like Homeodomain 1 (PITX1) interaction partners

  1. Pitx1 and the related protein Pitx2c are required for endogenous cement gland development. Pitx1 transcriptionally activates cement gland differentiation genes, both directly and indirectly

  2. Pitx1 is expressed in hindlimbs and expression is similar in both developing and regenerating limb buds.

Profil protéine PITX1

Profil protéine

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.

Gene names and symbols associated with PITX1

  • paired like homeodomain 1 (PITX1)
  • paired like homeodomain 1 (pitx1)
  • paired like homeodomain 2 (PITX2)
  • paired-like homeodomain 1 (Pitx1)
  • paired-like homeodomain 1 (pitx1)
  • paired-like homeodomain transcription factor 1 (Pitx1)
  • Pitx1 protein (pitx1)
  • Bft Protéine
  • CCF Protéine
  • LBNBG Protéine
  • MGC79589 Protéine
  • P-OTX Protéine
  • PITX1 Protéine
  • Potx Protéine
  • Ptx1 Protéine
  • X-PITX-1 Protéine
  • xPitx1 Protéine
  • zgc:136976 Protéine

Protein level used designations for PITX1

paired-like homeodomain 1 , paired-like homeodomain transcription factor 1 , pituitary homeobox 1 , Pitx2 , hindlimb expressed homeobox protein backfoot , hindlimb-expressed homeobox protein backfoot , homeobox protein PITX1 , pituitary homeo box 1 , pituitary otx-related factor , cPTX1 , homeobox protein P-OTX , pituitary OTX-related factor , xPitx1

462072 Pan troglodytes
493226 Xenopus (Silurana) tropicalis
508754 Bos taurus
100009361 Oryctolagus cuniculus
5307 Homo sapiens
374201 Gallus gallus
481513 Canis lupus familiaris
113983 Rattus norvegicus
678598 Danio rerio
18740 Mus musculus
398122 Xenopus laevis
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