Peroxiredoxin 6 Protéines (PRDX6)

The protein encoded by PRDX6 is a member of the thiol-specific antioxidant protein family. De plus, nous expédions Peroxiredoxin 6 Anticorps (212) et Peroxiredoxin 6 Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PRDX6 9588 P30041
PRDX6 11758 O08709
PRDX6 94167 O35244
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Top Peroxiredoxin 6 Protéines sur anticorps-enligne.fr

Showing 10 out of 30 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,570.39
Détails
Escherichia coli (E. coli) Humain Inconjugué 100 μg 2 to 3 Days
$345.00
Détails
Escherichia coli (E. coli) Humain His tag   100 μg 14 to 16 Days
$505.35
Détails
Escherichia coli (E. coli) Humain His tag   50 μg 4 Days
$522.50
Détails
Escherichia coli (E. coli) Humain His tag   100 μg 15 to 18 Days
$448.00
Détails
Escherichia coli (E. coli) Souris His tag   100 μg 15 to 18 Days
$608.00
Détails
Escherichia coli (E. coli) Humain His tag Validation with Western Blot 10 μg 4 to 8 Days
$396.00
Détails
Escherichia coli (E. coli) Rat Inconjugué SDS-PAGE analysis of Rat Peroxiredoxin 6 Protein. 100 μg 11 to 18 Days
$464.30
Détails
Wheat germ Humain GST tag 10 μg 11 to 12 Days
$414.29
Détails

PRDX6 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,
,

Peroxiredoxin 6 Protéines mieux référencés

  1. Mouse (Murine) Peroxiredoxin 6 Protein expressed in Escherichia coli (E. coli) - ABIN5665186 : Zhao, Du, Zhou, Liu, Gu, Long: Differences in Proinflammatory Property of Six Subtypes of Peroxiredoxins and Anti-Inflammatory Effect of Ligustilide in Macrophages. dans PLoS ONE 2016 (PubMed)

  2. Human Peroxiredoxin 6 Protein expressed in Wheat germ - ABIN1316165 : Jo, Yun, Park, Park, Lee, Cho, Yoo, Lee, Jeong, Kim, Jung, Hwang, Lee, Kim, Han, Hong: Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. dans PLoS ONE 2014 (PubMed)

Plus protéines pour Peroxiredoxin 6 (PRDX6) partenaires d'interaction

Human Peroxiredoxin 6 (PRDX6) interaction partners

  1. Patients with low Prx6 levels might be more prone to treatment-related adverse effects through elevated levels of oxidative stress.

  2. These findings highlight the importance of Prdx6 as an essential regulator of oxidative stress in the eye.

  3. These results suggest that there are distinct prognostic values of PRDX family members in patients with ovarian cancer, and that the expression of PRDX3, PRDX5, and PRDX6 mRNAs are a useful prognostic indicator in the effect of chemotherapy in ovarian cancer patients.

  4. we examined the therapeutic efficacy of the Ginkgolic acid (GA), a Sumoylation antagonist, to disrupt aberrant Sumoylation signaling in human and mouse lens epithelial cells (LECs) ...our study revealed an unprecedented role for GA in LECs and provided new mechanistic insights into the use of GA in rescuing LECs from aging/oxidative stress-evoked dysregulation of Sp1/Prdx6 protective molecules

  5. These findings demonstrated that PRDX6 expression plays a characteristic growth-promoting role in Colorectal Cancer metastasis.

  6. These findings implicate miR-371-3p as a suppressor of PRDX6 and suggest that co-targeting of peroxiredoxin 6 or modulating miR-371-3p expression together with targeted cancer therapies may delay or prevent acquired drug resistance.

  7. The present data suggest that PS2 mutations suppress lung tumor development by inhibiting the iPLA2 activity of PRDX6 via a gamma-secretase cleavage mechanism and may explain the inverse relationship between lung cancer and Alzheimer's disease incidence.

  8. The increased HDL and plasma levels of PRDX6 in AAA patients support the potential of PRDX6 as a new biomarker of AAA.

  9. These observations demonstrated that the expression and localization of NPM affected the homeostatic balance of oxidative stress in tumor cells via PRDX6 protein. The regulation axis of NPM/PRDX/ROS may provide a novel therapeutic target for cancer treatment.

  10. the transition-state substrate analogue inhibitor of Prdx6 phospholipase A2 activity (MJ-33) was shown to suppress Nox1 activity, suggesting Nox1 activity is regulated by the phospholipase activity of Prdx6. Finally, wild type Prdx6, but not lipase or peroxidase mutant forms, supports Nox1-mediated cell migration in the HCT-116 colon epithelial cell model of wound closure

  11. The constitutive elevations of Prdx6 and NF-kappaB during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis.

  12. Peroxidase activity was markedly reduced by mutation at either of the Leu sites and was essentially abolished by the double mutation, while PLA2 activity was unaffected. Decreased peroxidase activity following mutation of the interfacial leucines presumably is mediated via impaired heterodimerization of Prdx6 with piGST that is required for reduction and re-activation of the oxidized enzyme.

  13. PRX6 protein is associated with fetal esophageal development and cancer differentiation.

  14. Mutational analysis of functional sites showed that both peroxidase and PLA2 active sites were necessary for mutant Prdx6 function, and that Prdx6 phosphorylation (at T177 residue) was essential for optimum PLA2 activity.Mutant Prdx6 at its Sumo1 sites escapes and abates this adverse process by maintaining its integrity and gaining function

  15. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 activity of PRDX6 promoted cancer cell death induced by TNF-alpha.

  16. the data demonstrate that Prdx6 interrupts the formation of TRAF6-ECSIT complex induced by TLR4 stimulation, leading to suppression of bactericidal activity because of inhibited mROS production in mitochondria and the inhibition of NF-kappaB activation in the cytoplasm.

  17. Thus far only the crystal structure of Prx in the oxidized state has been reported. In this study, we present the crystal structures of human Prx6 in the reduced (SH) and the sulfinic acid (SO2H) forms.

  18. Peroxiredoxin 6 has a role in the repair of peroxidized cell membranes and cell signaling [review]

  19. PRDX6-anion exchanger 1 interaction contributes to the maintenance of anion exchanger 1 during cellular stress such as during metabolic acidosis.

  20. Prdx6 is a complete enzyme comprising both PLA2and LPCAT activities

Mouse (Murine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. IE-HBO can potentiate the production and the activity of Prdx6.

  2. Host Prdx6 can increase the intracellular survival of B. suis S2 strain and plays a role in Brucella infection.

  3. PRDX6 inhibits the neurogenesis of neural precursor cells through TLR4-dependent downregulation of WDFY1.

  4. PRDX6 has a critical role in the protection of the mouse spermatozoon against oxidative stress to assure fertilizing competence.

  5. we examined the therapeutic efficacy of the Ginkgolic acid (GA), a Sumoylation antagonist, to disrupt aberrant Sumoylation signaling in human and mouse lens epithelial cells (LECs) ...our study revealed an unprecedented role for GA in LECs and provided new mechanistic insights into the use of GA in rescuing LECs from aging/oxidative stress-evoked dysregulation of Sp1/Prdx6 protective molecules

  6. Data (including data from studies in transgenic rats and knockout mice) suggest that Nfe2l2 and Prdx6 are involved in biosynthesis of palmitic acid ester of 9-hydroxystearic acid in white adipose tissue (WAT); these proteins appear to be play roles in defense against oxidative stress in WAT. (Nfe2l2 = nuclear factor erythroid 2-like 2 nuclear factor; Prdx6 = peroxiredoxin-6)

  7. Our data indicate that a lack of the antioxidant enzyme PRDX6 protects against the development of acute and chronic experimental colitis and is associated with increased expression and function of other antioxidant enzymes

  8. The constitutive elevations of Prdx6 and NF-kappaB during Clonorchis sinensis infection may be associated with more severe persistent hepatobiliary abnormalities mediated by clonorchiasis.

  9. Detailed analysis of the redox-active cysteine in one protein in the nerve of old mice that is key to redox signalling (Peroxiredoxin 6, Cys 47) showed a minor increase in reversible oxidation that would be compatible with a change in its redox signalling function

  10. The results suggest that PRDX1 contributes to host defenses against M. tuberculosis PRDX1 positively regulates IL-12 production by inducing c-Rel and activating p38 MAPK, and it positively regulates NO production by suppressing Arg1 expression in macrophages infected with M. tuberculosis.

  11. This study indicated that Prdx6 decreased LPS-induced Muc5ac increase and played important roles in mucin hypersecretion after LPS exposure.

  12. PRDX6 inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 activity of PRDX6 promoted cancer cell death induced by TNF-alpha.

  13. Studies in knockout and knock-in mice showed that the phospholipase A2 activity of peroxiredoxin 6 activates NOX2 in cultured pulmonary endothelial cells and alveolar macrophages, clarifying the metabolism of lysophosphatidyl chold to lysophosphatidic acid.

  14. Prdx6 knockout males are more vulnerable to oxidative stress than WT males, resulting in impairment of sperm quality and ability to fertilize the oocyte, compatible with the subfertility phenotype observed in these knockout mice.

  15. Thr can substitute for Ser for the enzymatic activities of Prdx6 but not for its targeting to LB. These results confirm an important role for LB Prdx6 in the degradation and remodeling of lung surfactant phosphatidylcholine.

  16. AP-3-dependent LB targeting is facilitated by protein/protein interaction between LIMP-2/SCARB2 and PRDX6 in vitro and in vivo

  17. Prdx6 plays a critical role in the repair of peroxidized phospholipids in cell membranes and the recovery of lung cells from peroxidative stress; the peroxidase and PLA(2) activity each contribute to the recovery process.

  18. The ventral signal observed from E13.5 to E18.5 colocalized with motor neuron markers Isl1/2 and FoxP1 and the strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord.

  19. PRDX6 has a role in controlling multiple sclerosis by suppressing inflammation and blood brain barrier disruption

  20. PRDX6 has an important role in dopaminergic neurodegeneration of Parkinson's disease.

Cow (Bovine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. study demonstrated involvement of cytosolic and calcium-independent phospholipase A(2) and the contribution of cyclooxygenase-2 products in E. coli invasion of brain microvascular endothelial cells

  2. dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by iPLA2.

  3. PRDX6 upregulation in cumulus-oocyte complexes during in vitro maturation is mutually regulated by both cell types.

Xenopus laevis Peroxiredoxin 6 (PRDX6) interaction partners

  1. Gene expressionof Prx6 increased during development, especially at stages 33-43 during formation of the lungs.

Pig (Porcine) Peroxiredoxin 6 (PRDX6) interaction partners

  1. The expression of porcine Prdx6 gene is up-regulated by C/EBPbeta and CREB.

  2. The SNP of PRDX6 gene was significantly associated with the intramuscular fat and water moisture.

Profil protéine Peroxiredoxin 6 (PRDX6)

Profil protéine

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell\; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Gene names and symbols associated with Peroxiredoxin 6 Protéines (PRDX6)

  • peroxiredoxin 6 (PRDX6)
  • peroxiredoxin 6 (Prdx6)
  • peroxiredoxin 6 (prdx6)
  • peroxiredoxin 6 S homeolog (prdx6.S)
  • peroxiredoxin 6 L homeolog (prdx6.L)
  • 1-Cys Protéine
  • 1-cysPrx Protéine
  • 9430088D19Rik Protéine
  • AA690119 Protéine
  • aiPLA2 Protéine
  • aop2 Protéine
  • Aop2-rs3 Protéine
  • Brp-12 Protéine
  • CC26 Protéine
  • CP-3 Protéine
  • GPx Protéine
  • Ltw-4 Protéine
  • Ltw4 Protéine
  • Lvtw-4 Protéine
  • mKIAA0106 Protéine
  • NSGP Protéine
  • NSGPx Protéine
  • ORF06 Protéine
  • p29 Protéine
  • PHGPX Protéine
  • Prdx5 Protéine
  • prdx6 Protéine
  • Prdx6-rs3 Protéine
  • PRX Protéine
  • prx-6 Protéine
  • prx6 Protéine
  • zgc:73360 Protéine

Protein level used designations for Peroxiredoxin 6 Protéines (PRDX6)

1-Cys PRX , 1-Cys peroxiredoxin , 24 kDa protein , acidic calcium-independent phospholipase A2 , antioxidant protein 2 , liver 2D page spot 40 , non-selenium glutathione peroxidase , peroxiredoxin-6 , red blood cells page spot 12 , 1-Cys Prx , anti-oxidant protein 2, related sequence 3 , peroxiredoxin 5, related sequence 3 , peroxiredoxin 6, related sequence 3 , NSGPx , aiPLA2 , thiol-specific antioxidant protein , PHGPx , anti-oxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2) , calcium-independent phospholipase A2 , ciliary body glutathione peroxidase , peroxiredoxin 6 , non-selenium glutathione phospholipid hydroperoxide peroxidase

GENE ID SPECIES
9588 Homo sapiens
11758 Mus musculus
94167 Rattus norvegicus
282438 Bos taurus
393778 Danio rerio
394706 Xenopus (Silurana) tropicalis
398641 Xenopus laevis
399434 Xenopus laevis
429062 Gallus gallus
496787 Xenopus (Silurana) tropicalis
100304983 Ictalurus punctatus
399538 Sus scrofa
100173342 Pongo abelii
101842872 Mesocricetus auratus
100731397 Cavia porcellus
480069 Canis lupus familiaris
101112748 Ovis aries
101691344 Mustela putorius furo
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