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PITPNA encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. De plus, nous expédions PITPNA Anticorps (53) et et beaucoup plus de produits pour cette protéine.
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Data show that phosphatidylinositol transfer protein alpha (PITPalpha) is involved in the function of mixed lineage kinase domain-like protein (MLKL) in necroptosis.
This protein has been found differentially expressed in thalami from patients with schizophrenia.
the PITPalpha structure has to relax to allow access to the Ser166 site, and this may occur at the membrane surface where PI delivery is required for receptor-mediated PLC signaling
the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed
platelet PITPalpha-mediated phosphoinositide signaling is inconsequential for in vivo hemostasis.
These results indicate a mechanism of suppression that bypasses a quantitative requirement for PITPalpha function.
Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals.
PITP alpha has a role with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes
The PITPalpha function in murine cells has no deleterious consequences for growth and bulk phospholipid metabolism.
Involved in phosphoionoitide homeostasis and signal transsduction (review)
These results identify a crucial role for PlTPalpha in netrin-1-induced neurite outgrowth, revealing a signalling mechanism for DCC/neogenin and PlTPalpha regulation.
phosphatidylinositol binding is an essential functional property of PITPalpha in vivo, and suggest a causal linkage between defects in lipid transport and glucose homeostasis and cerebellar inflammatory disease
This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.
phosphatidylinositol transfer protein, alpha
, phosphatidylinositol transfer protein alpha isoform
, ptdIns transfer protein alpha
, ptdInsTP alpha
, PI-TP 35 kda isoform
, phosphatidylinositol-transfer protein 35 kDa isoform
, Pitp alpha
, PtdIns transfer protein alpha