Plakophilin 3 Protéines (PKP3)

PKP3 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. De plus, nous expédions Plakophilin 3 Anticorps (72) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PKP3 11187 Q9Y446
PKP3 56460 Q9QY23
Rat PKP3 PKP3 293619  
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Showing 4 out of 4 products:

Catalogue No. Origin Source Conjugué Images Quantité Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Wheat germ Humain GST tag 10 μg 11 to 12 Days
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days

PKP3 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Plakophilin 3 (PKP3) partenaires d'interaction

Human Plakophilin 3 (PKP3) interaction partners

  1. The result of this study PKP3 as the oncogene candidate and a potential target for the treatment of ovarian cancer.

  2. Nasopharyngeal carcinoma (NPC) tissues display a significant high miR-149 and low PKP3 expressions indicating that both play an important role in NPC metastasis. Downregulation of miR-149 resulting in the increment of PKP3 expression. Also, N,N'-dinitrosopiperazine (DNP)-mediated PKP3 decrease was eliminated by miR-149 in NPC cells. This suggests that DNP may reduce PKP3 expression through upregulating miR-149.

  3. plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma

  4. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

  5. Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.

  6. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2).

  7. The results suggest that MMP7 over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.

  8. reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3.

  9. These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.

  10. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.

  11. Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3.

  12. The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.

  13. stratifin plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.

  14. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased

  15. Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis.

  16. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts.

  17. plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation

  18. loss of PKP3 expression during gastric adenocarcinoma progression may indicate an invasive phenotype.

  19. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype

  20. PKP3 mRNA can be used as a marker of subclinical disease in gastrointestinal cancer and thus holds potential clinical relevance as a predictor for disease outcome

Mouse (Murine) Plakophilin 3 (PKP3) interaction partners

  1. data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.

  2. PKP3 gene down regulation is associated with bladder cancer invasion.

  3. PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin

Profil protéine Plakophilin 3 (PKP3)

Profil protéine

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.

Gene names and symbols associated with Plakophilin 3 Protéines (PKP3)

  • plakophilin 3a (pkp3a)
  • plakophilin 3 (PKP3)
  • plakophilin-3 (LOC450921)
  • plakophilin 3 L homeolog (pkp3.L)
  • plakophilin 3 (Pkp3)
  • 2310056L12Rik Protéine
  • PKP3 Protéine
  • wu:fa97f09 Protéine
  • wu:fk69a12 Protéine
  • zgc:136656 Protéine

Protein level used designations for Plakophilin 3 Protéines (PKP3)

plakophilin 3 , plakophilin-3-like , plakophilin 3b , plakophilin-3

368397 Danio rerio
422994 Gallus gallus
450921 Pan troglodytes
100412402 Callithrix jacchus
446427 Xenopus laevis
11187 Homo sapiens
516247 Bos taurus
56460 Mus musculus
483399 Canis lupus familiaris
293619 Rattus norvegicus
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