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The protein encoded by PTGER1 is a member of the G protein-coupled receptor family. De plus, nous expédions Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Anticorps (70) et beaucoup plus de produits pour cette protéine.
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No significant differences in EP1 intensity were detected for histological, stage, grading, metastatic and recurrent subtypes in endometrial cancer.
COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival
Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema
suppression of EP1 prevented RAMA-induced FasL (Montrer FASL Protéines) suppression in CLT85 cells at both the mRNA and protein levels
A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.
NF-kappaB (Montrer NFKB1 Protéines) inhibitor suppressed 17-PT-PGE2-mediated FoxC2 (Montrer FOXC2 Protéines) upregulation. Immunohistochemistry showed p65 (Montrer GORASP1 Protéines), FoxC2 (Montrer FOXC2 Protéines), EP1 receptor and beta1-integrin were all highly expressed in the HCC (Montrer FAM126A Protéines) cases
COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.
through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7 (Montrer Adcy7 Protéines).
PGE2-enhanced MMP2 (Montrer MMP2 Protéines) expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB (Montrer CREB1 Protéines) phosphorylation in human cholangiocarcinoma cells.
Our study suggests that the PGE (Montrer LIPF Protéines) EP1 receptor regulates FAK (Montrer PTK2 Protéines) phosphorylation by activating the PKC (Montrer PRRT2 Protéines)/c-Src (Montrer SRC Protéines) and EGFR (Montrer EGFR Protéines) signal pathways, which may coordinately regulate adhesion and migration in HCC (Montrer FAM126A Protéines)
Loss of EP1 results in inactivation of Hif1alpha (Montrer HIF1A Protéines), increased oxygen consumption rate and thus increased osteoblast differentiation.
PGE2 serves as a central regulator of the Ren (Montrer REN1 Protéines)-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB (Montrer CREB1 Protéines) pathway.
Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke.
EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.
Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response
The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin (Montrer REN Protéines)-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.
Propose a mechanism whereby ANG II (Montrer AGT Protéines) increases COX-1 (Montrer PTGS1 Protéines)-derived PGE2 through the AT1R (Montrer AGTRAP Protéines)/PLA2 (Montrer PLA2G2A Protéines) pathway, which promotes ROS (Montrer ROS1 Protéines) production by EP1R/Nox2 (Montrer CYBB Protéines) signaling in the subfornical organ.
dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 (Montrer DDX53 Protéines) tumors in BALB/c mice
EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism.
Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.
PGE receptor EP1 subtype
, PGE receptor, EP1 subtype
, PGE2 receptor EP1 subtype
, prostaglandin E receptor 1, subtype EP1
, prostaglandin E2 receptor EP1 subtype
, prostanoid EP1 receptor
, EP1 prostanoid receptor
, prostaglandin E receptor EP1 subtype
, prostaglandin E receptor 1 (subtype EP1), 42kDa
, prostaglandin E2 receptor subtype EP1