Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Protéines (PTGER1)

The protein encoded by PTGER1 is a member of the G protein-coupled receptor family. De plus, nous expédions Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Anticorps (73) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
PTGER1 5731 P34995
Rat PTGER1 PTGER1 25637 P70597
PTGER1 19216 P35375
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Top Prostaglandin E Receptor 1 (Subtype EP1), 42kDa Protéines sur

Showing 4 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human EP1 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days

PTGER1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Plus protéines pour Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) partenaires d'interaction

Human Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) interaction partners

  1. No significant differences in EP1 intensity were detected for histological, stage, grading, metastatic and recurrent subtypes in endometrial cancer.

  2. COX-2 expression appears to be linked to early hepatocellular carcinoma events (initiation), while EP1 receptor expression may participate in tumor progression and predict survival

  3. Copy number variation in PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema

  4. suppression of EP1 prevented RAMA-induced FasL suppression in CLT85 cells at both the mRNA and protein levels

  5. A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.

  6. NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Immunohistochemistry showed p65, FoxC2, EP1 receptor and beta1-integrin were all highly expressed in the HCC cases

  7. COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.

  8. through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7.

  9. PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells.

  10. Our study suggests that the PGE EP1 receptor regulates FAK phosphorylation by activating the PKC/c-Src and EGFR signal pathways, which may coordinately regulate adhesion and migration in HCC

  11. PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction

  12. Suggest that the anti-carcinogenic effects of EGCG in hepatocellular carcinoma might be mediated, at least partially, through the suppressing EP(1) receptor expression and PGE(2) production.

  13. new role for the EP(1) receptor in resolving inflammation through down-regulation of COX-2.

  14. Neuroblastoma express all four forms of PGE(2) receptors.

  15. A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.

  16. The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.

  17. Data indicate that not only Cox-2 but also EP1 and EP3 could be important targets for chemosensitization and inhibition of metastasis in breast cancers that are resistant to chemotherapy.

  18. EP1 functions as a suppressor of tumor metastasis; loss of nuclear EP1 is associated with poorer overall survival and may contribute to disparities in outcome in different populations.

  19. We could not find an association of EP1 gene with suicide in the Japanese population

  20. the PGE(2) and EP1 interaction enhanced migration of oral cancer cells through an increase in ICAM-1 production

Mouse (Murine) Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1) interaction partners

  1. Loss of EP1 results in inactivation of Hif1alpha, increased oxygen consumption rate and thus increased osteoblast differentiation.

  2. PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.

  3. Our study identifies the EP1 signaling pathway as an important link between neuroinflammation and MMP-mediated BBB breakdown in ischemic stroke.

  4. EP1-/- mice maintain increased bone mineral density and stronger cortical and trabecular bone biomechanical properties with aging. The EP1 receptor acts to inhibit bone marrow osteoprogenitor cell differentiation and mineralization.

  5. Results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response

  6. The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy.

  7. Propose a mechanism whereby ANG II increases COX-1-derived PGE2 through the AT1R/PLA2 pathway, which promotes ROS production by EP1R/Nox2 signaling in the subfornical organ.

  8. dietary administration and direct injection of the EP1 receptor-specific antagonist, ONO-8713, effectively reduced the growth of established CT26 tumors in BALB/c mice

  9. EP1 deletion protects mice from asymmetrical Parkinsonism. The PGE2 EP1 receptor is implicated in 6-OHDA-induced Parkinsonism.

  10. Data suggest that EP1 receptor blockade may be a viable target for antihypertensive therapy.

  11. data suggest that the tumor promoting/progressing effects of EP1 require the PGE2 synthesized by COX-2

  12. Peripheral EP1 receptors contribute significantly to inflammation induced heat pain sensitization while evidence for a contribution to central sensitization was not obtained.

  13. Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression.

  14. study provides firm evidence for the direct action of the PGE2-EP1 signaling on dopaminergic regulation in the midbrain. This EP1 action may explain the impulsive behaviors of Ptger1-/- mice due to a hyperdopaminergic state.

  15. impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in this receptor

  16. both the EP1 and the EP3 receptors play a role in fever induced by systemic inflammation but neither EP receptor is involved in the circadian rise in Tc or psychological stress-induced hyperthermia in mice.

  17. EP(1) receptor is of major importance for colon cancer development and it could be a new target for a mechanism-based chemoprevention strategy against colon cancer development.

  18. host EP1 and prostaglandin E receptor 3 receptors are involved in the control of local tumor growth, which translates into anorexia

  19. the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the hyperprostaglandin E syndrome/antenatal Bartter syndrome model

  20. prostaglandin E(2) acts through EP1 to control impulsive behavior under stress

Profil protéine Prostaglandin E Receptor 1 (Subtype EP1), 42kDa (PTGER1)

Profil protéine

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.

Gene names and symbols associated with PTGER1

  • prostaglandin E receptor 1 (PTGER1)
  • prostaglandin E receptor 1 (Ptger1)
  • prostaglandin E receptor 1 (subtype EP1), 42kDa (PTGER1)
  • prostaglandin E receptor 1 (subtype EP1) (Ptger1)
  • 42kDa Protéine
  • EP1 Protéine
  • PTGER1 Protéine
  • Ptgerep1 Protéine

Protein level used designations for PTGER1

PGE receptor EP1 subtype , PGE receptor, EP1 subtype , PGE2 receptor EP1 subtype , prostaglandin E receptor 1, subtype EP1 , prostaglandin E2 receptor EP1 subtype , prostanoid EP1 receptor , EP1 prostanoid receptor , prostaglandin E receptor EP1 subtype , prostaglandin E receptor 1 (subtype EP1), 42kDa , prostaglandin E2 receptor subtype EP1

5731 Homo sapiens
25637 Rattus norvegicus
747643 Pan troglodytes
100008680 Oryctolagus cuniculus
19216 Mus musculus
100855637 Canis lupus familiaris
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