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PCDH1 belongs to the protocadherin subfamily within the cadherin superfamily.
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Results show that PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Its expression is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair.
PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation.
PCDH1 and SMAD3 (Montrer SMAD3 Kits ELISA) act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta (Montrer TGFB1 Kits ELISA).
Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood
PCDH1 gene variant IVS3-116 associates with eczema in two independent birth cohorts in Netherlands.
PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains; enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells.
PCDH1 is a novel gene for BHR in adults and children. Its identification as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium and contributes to the development of BHR.
Pcdh1 is highly homologous to human PCDH1, encodes two transmembrane proteins and one intracellular protein, and is regulated by cigarette smoke exposure in vivo.
The tight spatial and temporal regulation of Pcdh1 expression suggests that this protocadherin plays multiple roles not only during development but also in mature tissues and organs in the mouse.
AXPC functions in notochord morphogenesis by directing cell-fate decisions rather than cell-cell adhesion.
we characterized pcdh1a, pcdh1b, pcdh7a, pcdh7b, and pcdh9 during the development of the zebrafish nervous system
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.
, cadherin-like protein 1
, protocadherin 42
, protocadherin 1 (cadherin-like 1)
, axial protocadherin