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PCDH17 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily.
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Cow (Bovine) Polyclonal PCDH17 Primary Antibody pour WB - ABIN2785751
Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. dans Genome biology 2008
Mouse (Murine) Polyclonal PCDH17 Primary Antibody pour ELISA, WB - ABIN4347946
Giefing, Zemke, Brauze, Kostrzewska-Poczekaj, Luczak, Szaumkessel, Pelinska, Kiwerska, Tönnies, Grenman, Figlerowicz, Siebert, Szyfter, Jarmuz: High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma. dans Genes, chromosomes & cancer 2011
PCDH17 methylation in serum is a potential prognostic biomarker for patients with renal cell carcinoma (Montrer MOK Anticorps) after surgery.
PCDH17 functions as a tumor suppressor inhibiting Wnt (Montrer WNT2 Anticorps)/beta-catenin (Montrer CTNNB1 Anticorps) signaling and metastasis in breast cancer but is frequently methylated in primary tumors which could be a potential biomarker.
Aberrant methylation of protocadherin 17 is associated with acute lymphoblastic leukemia.
PCDH-17 inhibited metastasis via EGFR (Montrer EGFR Anticorps)/MEK (Montrer MAP2K1 Anticorps)/ERK (Montrer EPHB2 Anticorps) signaling pathway.
DNA methylation (Montrer HELLS Anticorps) in a combination of POU4F2 (Montrer POU4F2 Anticorps)/PCDH17 has yielded the highest sensitivity and specificity of 90.00% and 93.96% in all the 312 individuals, showing the capability of detecting bladder cancer effectively among pathologically varied sample groups.
PCDH17 methylation in serum is a frequent event in early-stage prostate cancer, and it is an independent predictor of BCR (Montrer BCR Anticorps) after radical prostatectomy
PCDH17 methylation occurred more frequently and was associated with malignant clinicopathological characteristics and poor prognosis in clear cell renal cell carcinoma (Montrer MOK Anticorps) patients
PCDH17 promoter methylation is closely associated with bladder cancer malignancy and may be used as an independent predictor of clinical outcomes in patients with bladder cancer.
PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer
This study demonistrated that critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors.
Pcdh17 recruits the WAVE complex, Lamellipodin (Montrer RAPH1 Anticorps), and Ena/VASP (Montrer VASP Anticorps) to cell-cell contacts, converting these sites into motile structures.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.