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RASD1 encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. De plus, nous expédions RASD1 Anticorps (31) et RASD1 Protéines (7) et beaucoup plus de produits pour cette protéine.
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Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation.
Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 protein Dexras1 (RASD1).
Loss of RASD1 is associated with prostate cancer.
Study showed that Rasd1 and NonO interact at the CRE-site of specific target genes.
Rasd1 modulates endogenous renin gene expression by interacting with Ear2.
A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness
plays an active role in preventing aberrant cell growth
yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells demonstrate a direct interaction between AGS1 and the G(beta1) subunit of heterotrimeric G proteins
does not alter the membrane translocation of protein kinase C delta.
Dexras1 plays a critical role in shaping the photic phase response curve (PRC) and the signaling events through which it regulates clock entrainment in transgenic mice.
dex-ras1 mRNA is not induced by glucocorticoid stimulation in HEK293 cells
Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1
Epigenetic inactivation of genes, including RASD1, plays a key role in the development of dexamethasone resistance in multiple myeloma.
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
activator of G-protein signaling 1
, dexamethasone-induced Ras-related protein 1
, ras-related protein
, DEXRAS1 (Dexras1)