RAS, Dexamethasone-Induced 1 (RASD1) Kits ELISA

Human RAS, Dexamethasone-Induced 1 (RASD1) interaction partners

1. Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation.

2. Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 protein Dexras1 (RASD1).

3. Loss of RASD1 is associated with prostate cancer.

4. Study showed that Rasd1 and NonO interact at the CRE-site of specific target genes.

5. Rasd1 modulates endogenous renin gene expression by interacting with Ear2.

6. A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness

7. plays an active role in preventing aberrant cell growth

8. yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells demonstrate a direct interaction between AGS1 and the G(beta1) subunit of heterotrimeric G proteins

9. does not alter the membrane translocation of protein kinase C delta.

10. Dexras1 plays a critical role in shaping the photic phase response curve (PRC) and the signaling events through which it regulates clock entrainment in transgenic mice.

11. dex-ras1 mRNA is not induced by glucocorticoid stimulation in HEK293 cells

12. Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1

13. Epigenetic inactivation of genes, including RASD1, plays a key role in the development of dexamethasone resistance in multiple myeloma.