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may bind c-Jun N-terminal kinase (JNK); may play a role in JNK and Bruton's tyrosine kinase (Btk) mediated signaling pathways. De plus, nous expédions SH3-Domain Binding Protein 5 (BTK-Associated) Protéines (7) et SH3-Domain Binding Protein 5 (BTK-Associated) Kits (3) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 35 products:
Human Monoclonal SH3BP5 Primary Antibody pour IF, IHC (p) - ABIN564087
Win, Than, Fernandez-Checa, Kaplowitz: JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. dans Cell death & disease 2014
SH3BP5, LMO3 (Montrer LMO3 Anticorps), and SNAP25 (Montrer SNAP25 Anticorps) were expressed in diffuse large B-cell lymphoma cells and associated with clinical features.
REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11.
The interplay of p-JNK (Montrer MAPK8 Anticorps) with mitochondrial Sab leads to impaired respiration, ROS (Montrer ROS1 Anticorps) production, sustained JNK (Montrer MAPK8 Anticorps) activation, and apoptosis.
SH3BP5 binds to JNK (Montrer MAPK8 Anticorps) and directly inhibits JNK (Montrer MAPK8 Anticorps) through its two putative mitogen-activated protein kinase (Montrer MAPK1 Anticorps) interaction motifs (KIMs).
mitochondrial protein (Montrer COX6B2 Anticorps) Sab is phosphorylated by stress-activated protein kinase 3 (Montrer MAPK12 Anticorps)
The binding to and phosphorylation of Sab by p-JNK (Montrer MAPK8 Anticorps) on the outer mitochondrial membrane leads to SHP1 (Montrer PTPN6 Anticorps)-dependent and DOK4 (Montrer DOK4 Anticorps)-dependent inactivation of p-Src (Montrer SRC Anticorps) on the inner membrane; inactivation of mitochondrial Src (Montrer SRC Anticorps) inhibits electron transport and increases reactive oxygen species release, which sustains JNK (Montrer MAPK8 Anticorps) activation and promotes cell death and organ injury.
ER stress triggers an interaction of JNK (Montrer MAPK8 Anticorps) with mitochondrial Sab, which leads to impaired respiration and increased mitochondrial reactive oxygen species.
JNK (Montrer MAPK8 Anticorps)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF (Montrer TNF Anticorps)) requires mitochondrial Sab protein expression in mice
may bind c-Jun N-terminal kinase (JNK)\; may play a role in JNK and Bruton's tyrosine kinase (Btk) mediated signaling pathways
SH3 domain-binding protein 5
, SH3 domain-binding protein that preferentially associates with BTK
, vascular endothelial cell-specific protein 18