anti-Sestrin 2 (SESN2) Anticorps

SESN2 encodes a member of the sestrin family of PA26-related proteins. De plus, nous expédions Sestrin 2 Kits (14) et Sestrin 2 Protéines (8) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
SESN2 83667 P58004
SESN2 230784 P58043
SESN2 502988  
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Showing 10 out of 57 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-SESN2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate 100 μL 2 to 3 Days
Boeuf (Vache) Lapin Inconjugué WB 100 μL 2 to 3 Days
Humain Souris Inconjugué IF, ELISA, WB 100 μg 11 to 14 Days
Humain Lapin Inconjugué WB 100 μL 11 to 14 Days
Boeuf (Vache) Lapin Inconjugué WB 100 μL 11 to 14 Days
Humain Lapin Inconjugué IHC, WB ABIN6272847 at 1/100 staining Rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HEK-293 cells, using Sestrin 2 antibody. 100 μL 11 to 12 Days
Humain Souris Inconjugué IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to SESN2 on formalin-fixed paraffin-embedded human ovary, clear cell carcinoma. [antibody concentration 3 ug/ml] SESN2 monoclonal antibody (M03), clone 3B8 Western Blot analysis of SESN2 expression in K-562 100 μg 11 to 12 Days
Humain Lapin Inconjugué EIA, WB (LEFT) Western blot analysis of Sestrin-2 Antibody (Center) in 293 cell line lysates (35ug/lane). Sestrin-2 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of SESN2 (arrow) using rabbit polyclonal Sestrin-2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SESN2 gene (Lane 2). 0.4 mL 6 to 8 Days
Souris Lapin Inconjugué ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg 13 to 16 Days
Humain Lapin Inconjugué ELISA, IF, IHC (p), WB   0.1 mg 2 to 3 Days

anti-Sestrin 2 Anticorps mieux référencés

  1. Human Monoclonal Sestrin 2 Primary Antibody pour IF, IHC (p) - ABIN566510 : Liu, Lee, Lee: Association of platelet-derived growth factor receptor ? accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. dans FEBS letters 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Sestrin 2 Primary Antibody pour ICC, IF - ABIN4353033 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013 (PubMed)

Plus d’anticorps contre Sestrin 2 partenaires d’interaction

Human Sestrin 2 (SESN2) interaction partners

  1. Study found that SESN2 expression was significantly up-regulated in both hepatocellular carcinoma (HCC) cell lines and tissues. SESN2 activates AKT and AMPK signaling as a novel mechanism to induce sorafenib primary resistance in HCC.

  2. SESN2 up-regulation conferred primary resistance to sorafenib by activating AKT in hepatocellular carcinoma cells.

  3. SESN2 seems to play a role in the pathophysiology of preeclampsia, especially in severe preeclampsia cases.

  4. High serum Sestrin 2 levels are associated with metabolic synfrome.

  5. Knockdown of sesn2 aggravates atherosclerotic processes by increasing pro-inflammatory reactions and ER stress in the endothelium via an AMPK-dependent mechanism, suggesting that sesn2 might be a novel therapeutic target for atherosclerosis.

  6. SESN2 is critical to protect cells against detrimental effect of mitochondrial damage and RBX1 is a negative regulator of SESN2 which hampers its stabilization.

  7. Sesn2 ablation increased UVA-induced Nrf2 induction and inhibits UVA-induced ROS production, indicating that Sesn2 acts as an upstream regulator of Nrf2

  8. tribbles pseudokinase 3(TRB3) and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity

  9. Overexpression of Sesn2 downregulated the expression of autophagy genes, upregulated pro-apoptotic gene expression, and downregulated specific extracellular matrix markers in stress-induced cells.

  10. These results suggest that sestrin 2 suppresses CRC cell growth through activation of the AMPK/mTORC1 pathway and induction of apoptosis, and could be a novel pharmacological target for the treatment of CRC.

  11. This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 is necessary for the survival of glutamine-depleted lung cancer cells.

  12. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.

  13. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8-JUN-dependent transcriptional induction of SESN2

  14. The results suggest that SESN2 increases degradation of HIF-1A via AMPK-PHD regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.

  15. simple analysis of the reported "apo"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.

  16. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant a-helical structure.

  17. the results support a model in which leucine selectively promotes dephosphorylation of Sestrin2.

  18. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma

  19. These results highlight Sestrin2 as a novel tumor suppressor, whose downregulation can accelerate both colitis and colon carcinogenesis.

  20. The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4.

Mouse (Murine) Sestrin 2 (SESN2) interaction partners

  1. the decreased Sestrin2 levels in aging lead to an impaired AMPK/PGC-1alpha signaling cascade and an increased sensitivity to ischemic insults.

  2. Sestrin 2 may attenuate the activation of Hepatic Stellate Cell and ameliorate liver fibrosis, most likely via upregulation of AMPK phosphorylation and suppression of the mTOR signaling pathway.

  3. sesn2 has a role in lipopolysaccharide-induced oxidative stress in mice and in H9c2 cells

  4. Knockdown of sesn2 aggravates atherosclerotic processes by increasing pro-inflammatory reactions and ER stress in the endothelium via an AMPK-dependent mechanism, suggesting that sesn2 might be a novel therapeutic target for atherosclerosis.

  5. Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress.

  6. Sesn2 KO mice displayed enhanced expression of proinflammatory genes and activation of basilar membrane macrophages, suggesting that loss of SESN2 function provokes the immune response

  7. Aerobic physical exercise recovers Sestrin 2 protein content and induces autophagy in the skeletal muscle of old mice.

  8. While acute aerobic exercise increased Sesn1 accumulation and induced a discrete augment of Sesn2 protein content and AMPK threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 and Sesn2 as well as of AMPK threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.

  9. sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

  10. SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.

  11. Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.

  12. p53-dependent coordination with SESN2 regulates AMPK and mTORC1 signaling and controls parturition timing

  13. Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin signaling through the activation of AMPK signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin sensitivity and glucose metabolism via AMPK-dependent autophagic activation.

  14. Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1/Sesn2 signaling pathway.

  15. propose that Sestrin2 protects cells from glucose starvation-induced cell death via regulation of mitochondrial homeostasis

  16. Sestrin2 involved in the regulation of cardiomyopathy (such as myocardial fibrosis) after irradiation

  17. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

  18. suggest that TLR-mediated Sesn2 induction is dependent on AP-1, Nrf2, and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity

  19. Sestrin2 has a hepatoprotective role against chronic ER stress

  20. an AMPK-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.

Cow (Bovine) Sestrin 2 (SESN2) interaction partners

  1. SESN2 negatively regulates the mTORC1 pathway and subsequent CSN2 synthesis through the SH3BP4 in response to amino acids depletion.

Sestrin 2 (SESN2) profil antigène

Profil protéine

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

Gene names and symbols associated with anti-Sestrin 2 (SESN2) Anticorps

  • sestrin 2 (SESN2) anticorps
  • sestrin 2 (Sesn2) anticorps
  • sestrin 2 L homeolog (sesn2.L) anticorps
  • sestrin 2 (sesn2) anticorps
  • hi95 anticorps
  • MGC81239 anticorps
  • RGD1566319 anticorps
  • ses2 anticorps
  • SESN2 anticorps
  • sest2 anticorps
  • Sestrin-2 anticorps

Protein level used designations for anti-Sestrin 2 (SESN2) Anticorps

hypoxia induced gene 95 , sestrin-2 , sestrin 2 , sestrin-2-like

83667 Homo sapiens
230784 Mus musculus
414641 Xenopus laevis
469167 Pan troglodytes
487335 Canis lupus familiaris
509863 Bos taurus
716904 Macaca mulatta
733499 Xenopus (Silurana) tropicalis
100056552 Equus caballus
100172219 Pongo abelii
100353543 Oryctolagus cuniculus
100397149 Callithrix jacchus
100469808 Ailuropoda melanoleuca
100592235 Nomascus leucogenys
502988 Rattus norvegicus
100719606 Cavia porcellus
100149745 Danio rerio
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