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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. De plus, nous expédions SP7 Anticorps (37) et SP7 Kits (26) et beaucoup plus de produits pour cette protéine.
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Results provide evidence that CBP (Montrer CREBBP Protéines)-mediated acetylation and HDAC4 (Montrer HDAC4 Protéines)-mediated deacetylation have critical roles in the modification of Osx (Montrer MID1 Protéines), and thus are important in osteoblast differentiation.
Osterix and RUNX2 (Montrer RUNX2 Protéines) are transcriptional regulators of sclerostin (Montrer SOST Protéines) in human bone
Osterix decreased the chemosensitivity of breast cancer cells by upregulating the expression of GALNT14 (Montrer GALNT14 Protéines), which eventually suppressed the apoptosis of breast cancer cells.
TP(thymidine phosphorylase (Montrer TYMP Protéines) ) curbed the expression of three proteins-IRF8 (Montrer IRF8 Protéines), RUNX2 (Montrer RUNX2 Protéines), and osterix. This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (Montrer PIK3CA Protéines)/AKT (Montrer AKT1 Protéines) signaling and increased the methyltransferase DNMT3A's expression
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (Montrer CADM1 Protéines) and Osterix respectively. The other markers showed no statistical significance(CD151 (Montrer CD151 Protéines),ALP (Montrer ALP Protéines)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (Montrer CADM1 Protéines) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (Montrer BMP4 Protéines)-induced Cx43 (Montrer GJA1 Protéines) activity.
The expression of specific targets Smad1 (Montrer GARS Protéines) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (Montrer MUC7 Protéines)+). As miR (Montrer MLXIP Protéines)-30b, miR (Montrer MLXIP Protéines)-133a, and miR (Montrer MLXIP Protéines)-143 are negatively regulated by Pi and restored by Mg(2 (Montrer MUC7 Protéines)+) with a congruent modulation of their known targets Runx2 (Montrer RUNX2 Protéines), Smad1 (Montrer GARS Protéines), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (Montrer RUNX2 Protéines)-Osterix-BSP (Montrer KLK6 Protéines) Signaling.
Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (Montrer WNT2 Protéines)/beta-Catenin (Montrer CTNNB1 Protéines) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 (Montrer TGFBR2 Protéines) signaling and that decreased bone volume in Osx-Cre;Tgfbr2 (Montrer TGFBR2 Protéines)(fl/fl (Montrer FLT3LG Protéines)) mice is likely due to fewer mature osteoblasts.
DNA damage and senescence in osteoprogenitors expressing Osx may cause their decrease with age.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (Montrer MMP13 Protéines) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (Montrer PTH Protéines), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (Montrer WNT3A Protéines) induces Osx expression via p38 MAPK (Montrer MAPK14 Protéines) signaling in dental follicle cells. Wnt3a (Montrer WNT3A Protéines)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (Montrer MAPK14 Protéines) (MAPK (Montrer MAPK1 Protéines)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (Montrer KLK6 Protéines) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (Montrer KLK6 Protéines) promoter activated by Osx, a series of deletion mutants of Bsp (Montrer KLK6 Protéines) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (Montrer RELB Protéines) site was required for Bsp (Montrer KLK6 Protéines) promoter activation by Osx.
OSX served a key role in the development and progression of ALD-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2 (Montrer SATB2 Protéines)-induced osteogenic differentiation of BMSCs is regulated by miR (Montrer MLXIP Protéines)-27a.
Fibrillin-2 (Montrer FBN2 Protéines) and periostin (Montrer POSTN Protéines) are target genes in Osterix-mediated osteoblast differentiation.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, zinc finger protein osterix
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, trans-acting transcription factor 7
, Sp7 transcription factor 7