Spinster Homolog 2 (Drosophila) Protéines (SPNS2)

Sphingolipid transporter required for migration of myocardial precursors. De plus, nous expédions SPNS2 Anticorps (37) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SPNS2 216892 Q91VM4
SPNS2 100270678  
SPNS2 124976 Q8IVW8
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Showing 3 out of 3 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,355.45
Détails
Cellules d'insectes Humain rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Connectez-vous pour afficher 50 to 55 Days
$7,626.01
Détails
Escherichia coli (E. coli) Fruit Fly Inconjugué   5 applications Connectez-vous pour afficher 1 to 2 Days
$318.85
Détails

SPNS2 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine) ,

Rat (Rattus)
Human

Plus protéines pour Spinster Homolog 2 (Drosophila) (SPNS2) partenaires d'interaction

Zebrafish Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Toh is required for signaling by S1P (Montrer MBTPS1 Protéines)(2)and is involved in the trafficking or cellular release of S1P (Montrer MBTPS1 Protéines).

  2. findings show that Spns2 in the yolk syncytial layer functions as a sphingosine-1-phosphate (S1P (Montrer MBTPS1 Protéines)) transporter in S1P (Montrer MBTPS1 Protéines) secretion, thereby regulating myocardial precursor migration

Mouse (Murine) Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. genome-wide in vivo screen identifies novel host regulators of metastatic colonization, such as Spns2

  2. results point to a broad role for Spns2-mediated S1P (Montrer S1PR1 Protéines) transport in the initiation and development of adaptive immune related disorders

  3. Spns2 expression by endothelial cells is essential for secretion of lymph S1P (Montrer S1PR1 Protéines), while Spns2 is dispensable for RBC (Montrer CACNA1C Protéines) secretion of plasma S1P (Montrer S1PR1 Protéines).

  4. Spns2 is an S1P (Montrer S1PR1 Protéines) transporter in vivo that plays a role in regulation not only of blood S1P (Montrer S1PR1 Protéines) but also lymph node and lymph S1P (Montrer S1PR1 Protéines) levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  5. SPNS2 is the first physiological S1P (Montrer S1PR1 Protéines) transporter in mammals and is a key determinant of lymphocyte egress from the thymus.

  6. The changes in lymphocyte subpopulations in mutant Spns2 mice closely mimick the phenotypes of partial sphingosine-1-phosphate (S1P (Montrer S1PR1 Protéines)) deficiency, impaired S1P (Montrer S1PR1 Protéines)-dependent lymphocyte trafficking, and depletion of circulating lymphocytes.

  7. Spns2 functions in endothelial cells to establish the S1P (Montrer S1PR1 Protéines) gradient required for T and B cells to egress from their respective primary lymphoid organs.

  8. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

Human Spinster Homolog 2 (Drosophila) (SPNS2) interaction partners

  1. Butyrate and bioactive proteolytic form of Wnt-5a (Montrer WNT5A Protéines) regulate colonic epithelial proliferation and spatial development

  2. In both macrophage and epithelial cell types, Spns2 was also found localized to cytoplasm and the nucleus, in line with a predicted bipartile Nuclear Localization Signal at the position aa282 of the human Spns2 sequence

  3. A novel role for Spns2 and S1P1 (Montrer S1PR1 Protéines)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.

  4. Spns2 plays key roles in regulating the cellular functions in non-small cell lung cancer (NSCLC) cells

  5. mammals. These findings indicate that Spns2 is required for normal maintenance of the endocochlear potential and hence for normal auditory function, and support a role for S1P (Montrer MBTPS1 Protéines) signalling in hearing.

  6. Spns2 is an S1P (Montrer MBTPS1 Protéines) transporter in vivo that plays a role in regulation not only of blood S1P (Montrer MBTPS1 Protéines) but also lymph node and lymph S1P (Montrer MBTPS1 Protéines) levels and consequently influences lymphocyte trafficking and lymphatic vessel network organization.

  7. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

Profil protéine SPNS2

Profil protéine

Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

Gene names and symbols associated with SPNS2

  • spinster homolog 2 (Drosophila) (SPNS2)
  • spinster homolog 2 (Drosophila) (spns2)
  • sphingolipid transporter 2 (SPNS2)
  • spinster homolog 2 (spns2)
  • spinster homolog 2 (Spns2)
  • sphingolipid transporter 2 (Spns2)
  • DKFZp459J1933 Protéine
  • fi20h04 Protéine
  • si:dkey-7b17.4 Protéine
  • toh Protéine
  • wu:fi20h04 Protéine

Protein level used designations for SPNS2

spinster homolog 2 (Drosophila) , protein spinster homolog 2 , two of hearts , protein two of hearts , mCG6652-like , spinster-like protein , spinster2

GENE ID SPECIES
417492 Gallus gallus
568117 Danio rerio
606858 Canis lupus familiaris
613889 Bos taurus
100072726 Equus caballus
100145187 Xenopus (Silurana) tropicalis
100172034 Pongo abelii
216892 Mus musculus
100270678 Rattus norvegicus
124976 Homo sapiens
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