Split Hand/foot Malformation (Ectrodactyly) Type 1 Protéines (SHFM1)

The product of SHFM1 has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. De plus, nous expédions SHFM1 Anticorps (44) et SHFM1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
SHFM1 7979 P60896
SHFM1 20422 P60897
Rat SHFM1 SHFM1 680532  
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Top SHFM1 Protéines sur anticorps-enligne.fr

Showing 5 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Humain His tag 50 μg Connectez-vous pour afficher 13 to 16 Days
$492.31
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Boeuf (Vache) His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,082.67
Détails

SHFM1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1) partenaires d'interaction

Human Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1) interaction partners

  1. Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis.

  2. DSS1 is a multifunctional and intrinsically disordered protein. (Review)

  3. three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients

  4. SHFM1 confers cell cycle progression and resistance to p53 (Montrer TP53 Protéines) stabilizing drugs in gastric cancer cells.

  5. by targeting RPA (Montrer RPA1 Protéines) and mimicking DNA, DSS1 functions with BRCA2 (Montrer BRCA2 Protéines) in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression

  6. Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times.

  7. Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases.

  8. DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea (Montrer TREH Protéines)

  9. DSS1 has a role in homologous recombinational repair in human cells

  10. p63 (Montrer RPE65 Protéines) binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 (Montrer DLX5 Protéines) which are important for limb development.

Mouse (Murine) Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1) interaction partners

  1. 3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif

Profil protéine SHFM1

Profil protéine

The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.

Gene names and symbols associated with SHFM1

  • SEM1, 26S proteasome complex subunit (SEM1)
  • SEM1, 26S proteasome complex subunit (Sem1)
  • SEM1, 26S proteasome complex subunit S homeolog (sem1.S)
  • dss1 Protéine
  • ecd Protéine
  • sem1 Protéine
  • shfd1 Protéine
  • shfdg1 Protéine
  • Shfg Protéine
  • shfm1 Protéine
  • shfm1.S Protéine
  • shsf1 Protéine

Protein level used designations for SHFM1

26S proteasome complex subunit DSS1 , deleted in split hand/split foot protein 1 , deleted in split-hand/split-foot 1 , split hand/foot deleted protein 1 , split hand/foot malformation type 1 protein , candidate for split hand/foot malformation type 1 , 26 proteasome complex subunit DSS1 , split hand/foot malformation type 1 protein homolog , split hand/foot malformation (ectrodactyly) type 1 , deleted in split hand/split foot protein 1 homolog , split hand/foot deleted gene 1 , split hand/foot deleted protein 1 homolog , 26S proteasome complex subunit SEM1 , split hand/foot malformation (ectrodactyly) type 1 S homeolog

GENE ID SPECIES
7979 Homo sapiens
608719 Canis lupus familiaris
698349 Macaca mulatta
747549 Pan troglodytes
767981 Bos taurus
772237 Gallus gallus
100038817 Taeniopygia guttata
20422 Mus musculus
680532 Rattus norvegicus
100155621 Sus scrofa
447126 Xenopus laevis
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