Spondin 1 Protéines (SPON1)

Mouse (Murine) Spondin 1 (SPON1) interaction partners

1. Study identified a novel role for the extracellular matrix protein F-spondin in circadian behavior. In the absence of F-spondin, mice lost their ability to maintain typical intrinsic rhythmicity. Moreover, F-spondin loss results in the displacement of vasoactive intestinal peptide (VIP)-expressing neurons, a class of neurons that are essential for maintaining rhythmicity among suprachiasmatic nucleus neurons.

2. We conclude that upon ligand binding, TLR4 activates PI3K/Akt signaling to induce F-spondin expression, subsequently control CREB-mediated IL-6 production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis.

3. These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.

4. Spon1 deletion leads to a local and systemic reduction of TGF-beta levels resulting in increased BMP signaling and increased bone deposition in adult mice.

5. F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization.

Human Spondin 1 (SPON1) interaction partners

1. gene expression experiment revealed that CYP2B6, SPON1, and GSG1L can be activated concomitantly through a constitutive androstane receptor (CAR) activation pathway

2. SPON1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.

3. These data suggest that SPON1 may be associated with the differential rate of cognitive decline in Alzheimer disease.

4. High SPON1 expression is associated with high-grade gliomas.

5. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

6. downregulates osteoclast recruitment to the root side of periodontal tissue via low-density lipoprotein receptor-related protein 8 and inhibits differentiation of osteoclastic precursors

7. These findings indicate that F-spondin regulates the differentiation of human cementoblast-like cells via BMP7 expression.

8. The unique feature of F-spondin FS domain is the presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site.

9. expression profile of VSGP/F-spondin identifies this molecule as a potential diagnostic marker or target for developing therapeutic strategies to treat ovarian carcinoma

10. identified F-spondin as a promoting factor for cementoblastic differentiation

11. The crystal structure of the reelin-N domain resolved to 2.0 A reveals a variant immunoglobulin-like fold and potential heparin-binding sites.

12. These studies identify F-spondin as a novel protein in osteoarthritis cartilage, where it may act in situ at lesional areas to activate latent TGF-beta and induce cartilage degradation.

Pig (Porcine) Spondin 1 (SPON1) interaction partners

1. the porcine testis produces F-spondin and production of this protein is evident in the immature porcine testis, but not the adult testis.