Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) Protéines (TGM3)

Human Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM3) interaction partners

1. Cultured duodenal biopsies from patients with dermatitis herpetiformis produce transglutaminase-3 antibodies.

2. Levels of TG3-IgA IC significantly elevated in plasma as well as in serum samples of untreated patients with dermatitis herpetiformis compared with healthy controls.

3. studies demonstrate that TGase (Montrer F13A1 Protéines)-catalyzed transamidation and activation of rac1 and cdc42 (Montrer CDC42 Protéines) results from stimulation of multiple types of receptors and this novel signaling pathway can regulate dendritic spine morphology and plasticity.

4. The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.

5. Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 (Montrer TGM2 Protéines) mRNA levels by 2.9 fold.

6. Our data collectively demonstrate that TGM3 can be a candidate tumor suppressor that is able to induce esophageal cancer cell proliferation and migration

7. mRNA expression of transglutaminase 1 (Montrer TGM1 Protéines) and transglutaminase 3 was significantly decreased in patients with chronic periodontitis compared with a healthy control group.

8. Transglutaminase 3 present in the IgA aggregates in dermatitis herpetiformis skin is enzymatically active and binds soluble fibrinogen.

9. New basal cell carcinoma susceptibility loci were identified at TGM3 (rs214782) and RGS22 (Montrer RGS22 Protéines)(rs7006527).

10. IgA-anti-TG1 antibodies were found in 2% and IgA-anti-TG3 antibodies in 3% of patients with active atopic dermatitis (AD). Two out of the 5 patients with AD and concomitant celiac disease had IgA-anti-TG1 and IgA-anti-TG2 (Montrer TGM2 Protéines) antibodies.

Mouse (Murine) Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM3) interaction partners

1. study concludes that the classic wellhaarig mutations result from defects in Tgm3

2. The first signs of alopecia in mice of the +/Fgf5 (Montrer FGF5 Protéines)(go-Y) we/wewal/wal genotype appear only three days later than in double +/+ we/wewal/wal homozygotes.

3. Fluctuations of BMP2 (Montrer BMP2 Protéines) signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5 (Montrer FGF5 Protéines)(go).

4. Interaction of mutant genes Fgf5 (Montrer FGF5 Protéines)(go-Y), we, and wal changes the duration of hair growth cycles in mice

5. The clinically uninvolved skin in TGM3 knockout mice showed impaired barrier function and higher susceptibility to FITC sensitization indicating that TGM3 has a significant contribution to the functionally intact cutaneous barrier.

6. Loss of Tgm3 is associated with defective hair development.

7. new information on the specific distribution of TGase 3

8. The expression of TGM3 may play a important role in the epidermis differentiation in embryogenesis.