anti-Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) Anticorps

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].. De plus, nous expédions TNP1 Kits (12) et TNP1 Protéines (9) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
TNP1 7141 P09430
TNP1 21958 P10856
TNP1 24839 P02317
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Top anti-TNP1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 22 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-TNP1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate 100 μL 2 to 3 Days
$319.00
Détails
Chien Lapin Inconjugué IHC, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested. 100 μL 11 to 14 Days
$727.83
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of mouse testis tissue, using TNP1 antibody. ABIN6273179 at 1/100 staining Rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$390.77
Détails
Humain Souris Inconjugué ELISA, IHC, IHC (p), WB 100 μg 11 to 14 Days
$551.83
Détails
Humain Lapin Inconjugué ELISA, IHC   100 μL Disponible
$363.46
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL 2 to 3 Days
$446.88
Détails
Humain Lapin Inconjugué IHC, ELISA, WB   100 μg 15 to 19 Days
$527.03
Détails
Souris Lapin Inconjugué ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin- embedded liver tissue 100 μg 15 to 18 Days
$324.00
Détails
Humain Lapin Inconjugué WB TNP1 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Détails
Humain Souris Inconjugué IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TNP1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged TNP1 is approximately 0.03ng/ml as a capture antibody. 100 μg 11 to 12 Days
$440.00
Détails

anti-TNP1 Anticorps mieux référencés

  1. Human Polyclonal TNP1 Primary Antibody pour IHC, IHC (p) - ABIN4361286 : Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: The human testis-specific proteome defined by transcriptomics and antibody-based profiling. dans Molecular human reproduction 2014 (PubMed)

Plus d’anticorps contre TNP1 partenaires d’interaction

Cow (Bovine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. Sequence analysis revealed a deletion of "G" nucleotide in 3'UTR region of TNP1 and C>T SNP in intronic region of TNP2 gene. C>T SNP had a significant effect on initial progressive motility in purebred cattle and post-thaw motility in overall cattle population. RT-qPCR analysis did not reveal any significant variation in TNP1 and TNP2 gene expression among poorly motile and good quality spermatozoa of Vrindavani bulls.

  2. We propose that SNPs on the TNP1 3'-UTR may help select semen quality trait in Chinese Holstein bulls in the dairy industry.

Human Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.

  2. frequency of the haplotype GCG (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.

  3. a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility

  4. We found significantly lower levels of HILS1, TNP1, and TNP2 transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.

  5. The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.

  6. The presence of transition proteins (TP1 and/or TP2) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.

Mouse (Murine) Transition Protein 1 (During Histone To Protamine Replacement) (TNP1) interaction partners

  1. Tnp1, Tekt1, and Plzf have essential roles in spermatogenesis and can be expressed during organ culture of testis; with this system, genes can be induced only at the molecular level and not beyond meiosis.

  2. TPs are required for normal chromatin condensation, for reducing the number of DNA breaks, and for preventing the formation of secondary defects in spermatozoa, eventual loss of genomic integrity, and sterility

  3. The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis.

  4. Epididymal sperm from the Tnp1 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 processing with decreasing levels of transition proteins in mutant sperm.

  5. JHDM2A directly binds to and controls the expression of transition nuclear protein 1 (Tnp1) and protamine 1 (Prm1) genes, the products of which are required for packaging and condensation of sperm chromatin

TNP1 profil antigène

Profil protéine

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990

Gene names and symbols associated with TNP1

  • transition protein 1 (TNP1) anticorps
  • transition protein 1 (Tnp1) anticorps
  • STP-1 anticorps
  • TNP1 anticorps
  • TP-1 anticorps
  • TP1 anticorps

Protein level used designations for TNP1

transition protein 1 (during histone to protamine replacement) , STP-1 , TP-1 , spermatid nuclear transition protein 1 , testis-specific basic protein , Spermatid nuclear transition protein 1

GENE ID SPECIES
696593 Macaca mulatta
281537 Bos taurus
7141 Homo sapiens
100349146 Oryctolagus cuniculus
740418 Pan troglodytes
100630835 Equus caballus
21958 Mus musculus
24839 Rattus norvegicus
100513764 Sus scrofa
100686780 Canis lupus familiaris
101108026 Ovis aries
100724147 Cavia porcellus
102187724 Capra hircus
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