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Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. De plus, nous expédions TMEM59 Anticorps (34) et et beaucoup plus de produits pour cette protéine.
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identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 (Montrer LRP6 Protéines) and a positive regulator of Wnt (Montrer WNT2 Protéines) signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt (Montrer WNT2 Protéines)-FZD assemblies via intramembrane interactions.
The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.
TMEM59 affects amyloid precursor protein (Montrer APP Protéines) shedding by reducing its acccess to cellular components.
The results of this study revealed that DCF1-KO mice presented a visual behavioral deficit, higher GAD67 (Montrer GAD1 Protéines) levels, and lower electrophysiological activity in V1 via the GABA system.
Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY (Montrer NPY Protéines) and revealed that Dcf1 plays a critical role in energy balance.
MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.
The expression of tmem59 is an important factor contributing to Alzheimer's disease.
Chromosome mapping of 3 proteins (CRSP9 (Montrer MED7 Protéines), ETF1 (Montrer ETF1 Protéines) and TMEM59) in swine
Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
transmembrane protein 59
, liver membrane-bound protein
, thymic dendritic cell-derived factor 1