Transmembrane Protein 59 Protéines (TMEM59)

Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. De plus, nous expédions TMEM59 Anticorps (35) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Rat TMEM59 TMEM59 100196907  
TMEM59 9528 Q9BXS4
TMEM59 56374 Q9QY73
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Showing 6 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Souris rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Connectez-vous pour afficher 50 to 55 Days
$5,262.31
Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,749.58
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
$814.00
Détails
Wheat germ Humain GST tag 2 μg Connectez-vous pour afficher 11 to 12 Days
$338.33
Détails
Levure Orang-Utan His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,495.17
Détails
Levure Cynomolgus His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,495.17
Détails

TMEM59 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, , ,
Mouse (Murine)
,

Plus protéines pour Transmembrane Protein 59 (TMEM59) partenaires d'interaction

Human Transmembrane Protein 59 (TMEM59) interaction partners

  1. Results provide evidence that DCF1 plays an important role in controlling neuroblastoma (NB) tumor viability, promoting cell apoptosis, and inhibiting tumorigenesis in vivo. DCF1 could be a potential new inhibitor for components of the ERK1/2 signaling pathway and helped understand the molecular mechanism of NB.

  2. identify the single-span membrane protein TMEM59 as an interactor of FZD and LRP6 and a positive regulator of Wnt signaling. Mechanistically, TMEM59 promotes the formation of multimeric Wnt-FZD assemblies via intramembrane interactions.

  3. DCF1 subcellular localization and its function in mitochondria

  4. The TMEM59 gene identified from our discovery approach was recently implicated in amyloid-beta protein precursor post-translational processing, supporting a role for epigenetic change in LOAD pathology.

  5. TMEM59 affects amyloid precursor protein shedding by reducing its acccess to cellular components.

Mouse (Murine) Transmembrane Protein 59 (TMEM59) interaction partners

  1. Dcf1 triggers the dendritic spine and synaptic function through the recruitment of Lcn2 and activation of PSD95-NMDAR signaling.

  2. The Dcf1 knockout upregulates ATP1B1 expression in the hippocampus and DCF1 interaction with ATP1B1 in astrocytes impaired their structural plasticity.

  3. The results of this study revealed that DCF1-KO mice presented a visual behavioral deficit, higher GAD67 levels, and lower electrophysiological activity in V1 via the GABA system.

  4. Dcf1 plays an important role in behavior induced by the mushroom body in Drosophila and the dentate gyrus (DG) in mice and provides novel insights into their functions. Dcf1 rescued the optogenetic suppression of behavior by halorhodopsin in transgenic animals.

  5. Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance.

  6. This study shows that losing of dendritic cell factor 1 in the nervous system induces a social interaction deficit.

  7. MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates neural stem cell morphogenesis.

  8. The expression of tmem59 is an important factor contributing to Alzheimer's disease.

  9. Overexpression of the dcf1 gene, the NSCs were maintained in undifferentiated status. After the dcf1 gene was silenced, cells tended to differentiate into neurons and astrocytes.

Pig (Porcine) Transmembrane Protein 59 (TMEM59) interaction partners

  1. Chromosome mapping of 3 proteins (CRSP9, ETF1 and TMEM59) in swine

Profil protéine TMEM59

Profil protéine

Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).

Gene names and symbols associated with TMEM59

  • transmembrane protein 59 (tmem59)
  • transmembrane protein 59 (Tmem59)
  • transmembrane protein 59 (TMEM59)
  • 1110001M20Rik Protéine
  • 3110046P06Rik Protéine
  • AI256529 Protéine
  • C1orf8 Protéine
  • D4Ertd20e Protéine
  • HSPC001 Protéine
  • MTDCF1 Protéine
  • ORF18 Protéine
  • Tmem59 Protéine

Protein level used designations for TMEM59

transmembrane protein 59 , liver membrane-bound protein , thymic dendritic cell-derived factor 1

GENE ID SPECIES
566384 Danio rerio
100196907 Rattus norvegicus
9528 Homo sapiens
56374 Mus musculus
509775 Bos taurus
733610 Sus scrofa
479561 Canis lupus familiaris
100173202 Pongo abelii
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