Triggering Receptor Expressed On Myeloid Cells-Like 1 Protéines (TREML1)

Human Triggering Receptor Expressed On Myeloid Cells-Like 1 (TREML1) interaction partners

1. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels.

2. Levels of sTLT-1 in plasma from patients with potential acute coronary syndrome were compared with an age-matched control group with similar risk factors for cardiovascular disease.

3. Platelet-derived soluble TLT-1 is a potent endogenous regulator of sepsis-associated inflammation.

4. Serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for non-tuberculous mycobacterial lung disease.

5. These results suggest that during inflammation, sTLT-1 may mediate hemostasis by enhancing actin polymerization, resulting in increased platelet aggregation and adherence to the endothelium.

6. initial characterization of TREM-like transcript (TLT)-1 results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors(TLT-1)

7. In contrast to previously characterized immunoreceptor tyrosine-based inhibition motif (ITIM) receptors, TLT1 enhances rather than inhibits calcium signaling in rat RBL-2H3 cells, a property dependent on the SHP-2 recruiting classical Tyr281 ITIM.

8. A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin.

9. Define a platelet specific function for TLT1 in regulation of aggregation.

10. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1.

11. antibody against the extracellular domain inhibits platelet aggregation in vitro

12. TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury

Mouse (Murine) Triggering Receptor Expressed On Myeloid Cells-Like 1 (TREML1) interaction partners

1. TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.

2. initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors

3. expressed exclusively in platelets and megakaryocytes; expression is up-regulated upon platelet activation; is prepackaged into both MK and platelet alpha-granules; may regulate granule construction or dispersal

4. A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin.

5. TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury