sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Kits ELISA

SIGMAR1 encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. De plus, nous expédions SIGMAR1 Anticorps (51) et SIGMAR1 Protéines (10) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
SIGMAR1 10280 Q99720
SIGMAR1 18391 O55242
SIGMAR1 29336 Q9R0C9
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Plus Kits ELISA pour SIGMAR1 partenaires d'interaction

Human sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. the expression of sigma-1 receptor (S1R) in Schwann cell-like cells, was analysed.

  2. Novel nonsense mutation in the coding region of the SIGMAR1 gene causes recessive distal motor neuropathy with pyramidal signs in an Omani kindred.

  3. Cardiac sigma 1 receptors regulate response to endoplasmic reticulum stress, modulates calcium signaling in cardiomyocyte and can affect function of voltage-gated ion channels. They contributed in pathophysiology of cardiac hypertrophy, heart failure and many other cardiovascular disorders.

  4. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain.

  5. Findings indicate that sigma1R is decreased in hepatocellular carcinoma and is closely correlated with histological differentiation.

  6. mutation in Sigma receptor-1 leads to ER stress-mediated defects in protein homeostasis and dysregulation of RNA-binding proteins

  7. These findings indicate that a loss of Sig1R function is causative for juvenile amyotrophic lateral sclerosis (ALS16), and collapse of the mitochondria-associated membrane is a common pathomechanism in both Sig1R- and SOD1-linked ALS.

  8. Analyses of tissue microarray from colorectal cancer patients showed higher SigmaR1 expression levels in cancer samples and a correlation with tumor grade. Moreover, the exploration of a cohort of 4937 breast cancer patients indicated that high expression of SigmaR1 and Orai1 channels was significantly correlated to a lower overall survival.

  9. our data show that Sigma1 modulators can be used to suppress AR/ARV-driven prostate cancer cells via regulation of pharmacologically responsive Sigma1-AR/ARV interactions, both in vitro and in vivo

  10. Genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with Major Depressive Disorder and Bipolar Disorder.

  11. Data demonstrate the involvement of SIGMAR1 in motor neuron maintenance and survival by correlating mutations in this gene to distal motor dysfunction and highlight the chaperone activity of sigma-1R as a critical aspect in distal hereditary motor neuropathy pathology.

  12. Changes of Sig1R and SOD2 expression point to mitochondria as main organelle responsible for survival of tumor cells exposed to hypoxia or oxidative stress. Studied proteins are involved in intracellular response to stress related with different concentrations of oxygen.

  13. the sigma-1 receptor and the nNav1.5 channel formed a physical, functional complex

  14. Collectively, these studies define Sig1R as a key mediator of TRAIL induction of cancer-specific killing.

  15. crystal structures of the human sigma1 receptor in complex with two chemically divergent ligands, PD144418 and 4-IBP

  16. Expression of mutant Sig-1R protein reduces mitochondrial ATP production, inhibits proteasome activity and causes mitochondrial injury, aggravating ER stress-induced neuronal death.

  17. Recent studies indicate that sigma-1 receptors, partly in sake of its unique subcellular localization, regulate the mitochondria function that involves bioenergetics and free radical generation.

  18. Removal of the S1R gene in the Superoxide Dismutase-1 (SOD-1) mouse model of ALS exacerbated the neurodegenerative condition and resulted in a significantly reduced longevity.

  19. overview of the biological mechanisms frequently associated with neurodegeneration, and discuss how sigma-1 receptors may alter these mechanisms to preserve or restore neuronal function.

  20. mutations of the SIGMAR1 gene worsen outcome in Alzheimer's disease and myotrophic lateral sclerosis supporting a role of Sig-1R in neurodegenerative disease.

Mouse (Murine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. we identified a previously unexplored role of Sig-1R in alleviating blood-brain barrier disruption in stroke processes

  2. Drug exposures were simultaneously determined and correlated with sigma-1 occupancy from the same experiment. Wide category drugs can be assayed for sigma-1 receptor engagement and their correlation with exposures aid in clinical development.

  3. The current study demonstrates that rapidly dephosphorylated spinal astrocyte aromatase is associated with the development of formalin-induced acute nociception. Moreover, activation of astrocyte sigma-1 receptors leads to a calcineurin-mediated dephosphorylation of aromatase resulting in the rapid modulation of this enzyme.

  4. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain.

  5. Oprs1 neuroprotective effect has been demonstrated in a cell model of Huntington's disease.

  6. This study reveals previously uncharacterized S1R-associated mechanisms during rd10 photoreceptor degeneration

  7. l-THP possesses antinociceptive effects through spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain

  8. Results indicate that the sigma1R deficiency in basolateral amygdala principal neurons via NMDA recetpor dysfunction suppresses nNOS activity and NO production to reduce GABA-A receptor-mediated inhibition, which impairs long-term depression induction and causes depressive-like phenotype.

  9. Sigma 1 receptor (Sig1R) activation modifies intracellular calcium exchange in the G93A(hSOD1) amyotrophic lateral sclerosis model. Study shows, intracellular Ca(2+) shuttling can be manipulated by Sig1R activation.

  10. Chronic pharmacological stimulation of sigma1rs induces learning and memory behavioral improvement in an ischemia model. Significant neurorestorative effects may be favored by a BDNF neurotrophic effect. The involvement of an antagonist of NR2A revealed that the improvement of learning and memory impairment, mediated by BDNF through sigma1r activation, relied on the NR2A-induced CaMKIV-TORC1-p-CREB pathway.

  11. Expression of sigma-1 receptor is specifically increased in ischemic penumbral neurons within hours after middle cerebral artery occlusion.

  12. Its deficiency through enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination.

  13. Sig1R activation preserves retinal thickness and diminishes retinal detachment in Pde6beta mutant mice.

  14. Methamphetamine induced microglial apoptosis via its cognate receptor sigma-1R. Furthermore, this effect was mediated by activation of MAPKs and PI3K/Akt pathways and subsequent translocation of p53 into nucleus, resulting in activation of caspase, ultimately leading to cell apoptosis. sigma-1R plays a critical role in eliciting innate immune responses in microglia.

  15. Findings identified five alternatively spliced variants of the sigma1 receptor gene Sigmar1 using a polymerase chain reaction cloning approach.

  16. inhibition of Sig-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.

  17. Activation of S1R, necessary for its effect on the BDNF pathway, represents a core component of the mode of action of pridopidine. Since the newly identified pathways are downregulated in neurodegenerative diseases, including Huntington Disease (HD) , these findings suggest that pridopidine may exert neuroprotective effects beyond its role in alleviating some symptoms of HD.

  18. Findings demonstrate that spinal cord injury activates astrocyte sigma-1 receptors leading to increases in the expression of the gap junction protein, connexin 43 and astrocyte activation in the lumbar dorsal horn, and ultimately contribute to the induction of bilateral below-level mechanical allodynia.

  19. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane.

  20. The findings indicate that the activation of sigma1R can alleviate postpartum "depression" through increasing nNOS-NO-CREB activities.

Cow (Bovine) sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. Sig1R through Rac1 signaling induces mild oxidative stress that possibly is involved in the regulation of neuroplasticity

Guinea Pig sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) interaction partners

  1. S1R has a GXXXG motif in its second transmembrane region, and these motifs are often involved in oligomerization of membrane proteins. Disrupting mutations within the GXXXG motif shifted the fraction of the higher oligomeric states toward smaller states.

  2. novel functions of the sigma-1 receptor

SIGMAR1 profil antigène

Antigen Summary

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor\; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

Gene names and symbols associated with SIGMAR1

  • sigma non-opioid intracellular receptor 1 (SIGMAR1) anticorps
  • sigma non-opioid intracellular receptor 1 (Sigmar1) anticorps
  • sigma non-opioid intracellular receptor 1 L homeolog (sigmar1.L) anticorps
  • sigma non-opioid intracellular receptor 1 (sigmar1) anticorps
  • AL024364 anticorps
  • ALS16 anticorps
  • mSigmaR1 anticorps
  • oprs1 anticorps
  • SIG-1R anticorps
  • Sigma1R anticorps
  • SR-BP anticorps
  • SR-BP1 anticorps
  • SRBP anticorps
  • zgc:56378 anticorps

Protein level used designations for SIGMAR1

SR31747 binding protein 1 , aging-associated gene 8 protein , hSigmaR1 , sigma 1-type opioid receptor , opioid receptor, sigma 1 , sigma1-receptor , sigma1R , Sigma 1-type opioid receptor , Sigma1-receptor , sigma1-receptor (sterol-isomerase like protein) , sterol isomerase-like protein

GENE ID SPECIES
10280 Homo sapiens
18391 Mus musculus
29336 Rattus norvegicus
481587 Canis lupus familiaris
538903 Bos taurus
100859748 Gallus gallus
100135589 Cavia porcellus
100341228 Oryctolagus cuniculus
101116710 Ovis aries
446848 Xenopus laevis
393952 Danio rerio
100521392 Sus scrofa
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