STAT5A anticorps (AA 583-794)

N° du produit ABIN1098129

Cet anticorps anti-STAT5A est un anticorps Souris Monoclonal détectant STAT5A dans WB, IHC, ELISA, FACS et ICC. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour STAT5A anticorps (AA 583-794) (ABIN1098129)

Antigène: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT5A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 6D4

Détail du produit anti-STAT5A anticorps

Épitope: AA 583-794

Fonction: STAT5A Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human STAT5A (AA: 583-794 ) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-STAT5A (ABIN1098129)

Cerliani, Guillardoy, Giulianelli, Vaque, Gutkind, Vanzulli, Martins, Zeitlin, Lamb, Lanari: "Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer." dans: Cancer research, Vol. 71, Issue 10, pp. 3720-31, (2011) (PubMed).

Warsch, Kollmann, Eckelhart, Fajmann, Cerny-Reiterer, Hölbl, Gleixner, Dworzak, Mayerhofer, Hoermann, Herrmann, Sillaber, Egger, Valent, Moriggl, Sexl: "High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia." dans: Blood, Vol. 117, Issue 12, pp. 3409-20, (2011) (PubMed).

Détails sur STAT5A

Antigène: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Autre désignation: STAT5A

Sujet: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Poids moléculaire: 90.6 kDa

ID gène: 6776

UniProt: P42229

Pathways: Signalistation JAK/STAT, Signalisation RTK, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation