Ankyrin G anticorps (C-Term)

N° du produit ABIN1098195

Détail du produit anti-Ankyrin G anticorps

Antigène: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ankyrin G est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)

Fonction: Anti-Ankyrin-G Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Ankyrin-G.

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G affinity chromatography.

Immunogène: Fusion protein corresponding to ~1,000 C-terminal amino acids of human Ankyrin G (accession no. NP_066267.2).

Clone: S106-20

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-2 μg/mL. A band of >200 kDa is detected.
These are recommended concentrations.
Enduser should determine optimal concentrations for their applications.
Positive control: rat brain membranes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

Détails sur Ankyrin G

Antigène: Ankyrin G (ANK3) (Ankyrin 3, Node of Ranvier (Ankyrin G) (ANK3))

Autre désignation: Ankyrin-G (ANK3 Produits)

Synonymes: anticorps ANK3, anticorps ankyrin-G, anticorps 2900054D09Rik, anticorps AI314020, anticorps Ank-3, anticorps AnkG, anticorps Ankyrin-3, anticorps Ankyrin-G, anticorps ANKYRIN-G, anticorps ankyrin 3, anticorps ankyrin 3, node of Ranvier (ankyrin G), anticorps ankyrin 3, epithelial, anticorps ANK3, anticorps legA6, anticorps PB000272.02.0, anticorps PY00018, anticorps ank3, anticorps Ank3

Sujet: Ankyrin-3,In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {PubMed:17974005}., [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {PubMed:17974005}.,Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton. Ankyrins have binding sites for the beta subunit of spectrin and for at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers, and ion transporters in the plasma membrane.,Cytoplasm, cytoskeleton, Cell projection, axon, Cell membrane, sarcolemma, Cell junction, synapse, postsynaptic cell membrane, Lysosome, Cell membrane, sarcolemma, T-tubule,ANK-3, Ankyrin-G

UniProt: Q12955

Pathways: Synaptic Membrane, Maintenance of Protein Location, Skeletal Muscle Fiber Development