CLCN3 anticorps (AA 98-115)

N° du produit ABIN1098197

Détail du produit anti-CLCN3 anticorps

Antigène: CLCN3 (Chloride Channel 3 (CLCN3))

Épitope: AA 98-115

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CLCN3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)

Fonction: Anti-Chloride Channel Protein 3 Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Clcn3. It does not cross-react with Clcn4 or Clcn5.

Réactivité croisée: Humain, Souris, Rat

Réactivité croisée (Details): No cross Reactivity with Cav3.2

Purification: Purified by Protein G affinity chromatography.

Immunogène: Synthetic peptide correspond- ing to aa 98-115 (cytoplasmic N-terminus) of rat Clcn3 (accession no. NP_445815.2).

Clone: S258-5

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-2 μg/mL. A band of ~90 kDa is detected.
Immunohistochemistry: use at 1-10 μg/mL.
These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: Rat brain membranes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur CLCN3

Antigène: CLCN3 (Chloride Channel 3 (CLCN3))

Autre désignation: Chloride Channel Protein 3 (Clcn3) (CLCN3 Produits)

Synonymes: anticorps CLC3, anticorps ClC-3, anticorps Clc3, anticorps CLCN3, anticorps fb78c02, anticorps wu:fb78c02, anticorps clc3, anticorps clc-3, anticorps chloride voltage-gated channel 3, anticorps chloride channel, voltage-sensitive 3, anticorps chloride channel 3, anticorps chloride channel protein 3, anticorps chloride channel, voltage-sensitive 3 S homeolog, anticorps CLCN3, anticorps Clcn3, anticorps clcn3, anticorps PTRG_03131, anticorps BDBG_05668, anticorps MCYG_04420, anticorps clcn3.S

Sujet: H(+)/Cl(-) exchange transporter 3,[Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {UniProtKB:P51790, PubMed:10915634}., [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:10915634). May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C (PubMed:8155321). It could help neuronal cells to establish short-term memory (PubMed:8155321). {PubMed:10915634, PubMed:8155321}.,Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Clcn3 mediates the exchange of chloride ions against protons and functions as an antiporter, contributing to the acidification of the endosome and synaptic vesicle lumen. It may play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C.,[Isoform 1]: Lysosome membrane, Late endosome membrane, Cell membrane, Early endosome membrane,Chloride channel protein 3, ClC-3, Chloride transporter ClC-3

NCBI Accession: NP_445815

UniProt: P51792