SLC1A1 anticorps (AA 1-524)

N° du produit ABIN1098200

Détail du produit anti-SLC1A1 anticorps

Antigène: SLC1A1 (Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1))

Épitope: AA 1-524

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SLC1A1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC)

Fonction: Anti-EAAC1 Mouse Monoclonal Antibody

Specificité: This antibody recognizes human EAAC1.

Réactivité croisée: Humain

Purification: Purified by Protein G affinity chromatography.

Immunogène: Fusion protein corresponding to aa 1-524 (full-length) of human EAAC1 (accession no. NP_004161.4).

Clone: S180-41

Isotype: IgG1

Information d'application

Indications d'application: Immunoblotting: use at 1-5 μg/mL. A band of ~60 kDa is detected.
These are recommended concentrations.
Enduser should determine optimal concentrations for their applications.
Positive control: rat brain membranes.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

Détails sur SLC1A1

Antigène: SLC1A1 (Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1))

Autre désignation: EAAC1 (SLC1A1 Produits)

Synonymes: anticorps GB16911, anticorps EAAT3, anticorps SLC1A2a, anticorps zgc:91959, anticorps EAAC1, anticorps SCZD18, anticorps D130048G10Rik, anticorps EAAC2, anticorps MEAAC1, anticorps Eaac1, anticorps Eaat3, anticorps REAAC1, anticorps excitatory amino acid transporter 3, anticorps solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1, anticorps solute carrier family 1 member 1, anticorps LOC412382, anticorps slc1a1, anticorps SLC1A1, anticorps CpipJ_CPIJ000674, anticorps CpipJ_CPIJ001134, anticorps Slc1a1

Sujet: Excitatory amino acid transporter 3,Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport, this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). {UniProtKB:P51906, UniProtKB:P51907, PubMed:21123949, PubMed:26690923, PubMed:7521911, PubMed:7914198, PubMed:8857541}.,Excitatory amino-acid carrier 1 (EAAC1) is a high-affinity Na+-dependent L- glutamate/D,L-aspartate cell membrane transport protein. It is expressed in brain as well as in several non-nervous system tissues. In brain, EAAC1 is the primary neuronal glutamate transporter. It has a polarized distribution in cells and functions mainly perisynaptically to transport glutamate from the extracellular environment. In the kidney it is involved in renal acidic amino acid reabsorption and amino acid metabolism. EAAC1- associated protein GTRAP3-18 may be important in regulating the metabolic function of EAAC1.,Cell membrane, Apical cell membrane, Cell junction, synapse, synaptosome, Early endosome membrane, Late endosome membrane, Recycling endosome membrane,Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1

UniProt: P43005

Pathways: Dicarboxylic Acid Transport