alpha Fetoprotein anticorps

N° du produit ABIN1105332

Détail du produit anti-alpha Fetoprotein anticorps

Antigène: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp alpha Fetoprotein est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: C2 is characterized in the ISOBM TD-2 workshop and assigned by K. Nustad to group E of a cluster of 6 major epitopes of Human Alpha Fetoprotein. C2 specifically reacts with Human and Mouse AFP, but does not react with Rat, Dog or calf Alpha Fetoprotein as demonstrated by ELISA.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Purified

Immunogène: A BALB/c mouse has been immunized with alpha fetoprotein isolated from serum of hepatoma patients. Splenocytes were fused with mouse myeloma cell line P3-X63-Ag8.653.

Clone: C2

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0,1 mg/mL

Buffer: PBS, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur alpha Fetoprotein

Antigène: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Abstract: AFP Produits

Synonymes: anticorps FETA, anticorps HPAFP, anticorps alpha fetoprotein, anticorps alpha-fetoprotein, anticorps AFP, anticorps Afp

Sujet: Human alpha fetoprotein is an oncofetal protein of 70 kD. Its gene is cloned and sequenced and its structure identified. AFP is expressed in fetal liver and is normally absent in healthy adult tissues. It is expressed in all yolk sac tumors, in some germ cell tumors and in hepatocellular carcinomas. Alpha Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. alpha Fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha Fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha Fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha Fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha Fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.Synonyms: Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP

ID gène: 174

NCBI Accession: NP_001125

UniProt: P02771

Pathways: C21-Steroid Hormone Metabolic Process