IFNA anticorps

N° du produit ABIN1107768

Détail du produit anti-IFNA anticorps

Antigène: IFNA (Interferon alpha (IFNA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IFNA est non-conjugé

Application: Neutralization (Neut)

Aucune reactivité croisée: Souris

Réactivité croisée (Details): Species reactivity (tested):Human.

niveau d'endotoxine: < 10 ng/mg of antibody, as determined by the LAL assay

Immunogène: Human IFN-alpha (purified)

Clone: #14

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur IFNA

Antigène: IFNA (Interferon alpha (IFNA))

Autre désignation: Interferon alpha (IFN Alpha) (IFNA Produits)

Synonymes: anticorps IFN-alphaO, anticorps IFN-ALPHA-1, anticorps IFN1@, anticorps Ifa, anticorps Ifa8, anticorps interferon alpha 16, anticorps interferon, alpha 1, anticorps interferon alpha, anticorps interferon-alpha, anticorps IFNA16, anticorps IFNA1, anticorps Ifna, anticorps IFNA

Sujet: The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: B Cell Interferon, IFN-alpha, IFNA, Interferon-alpha, Leukocyte Interferon, Type I Interferon

Pathways: Signalistation JAK/STAT, Signalisation TLR, Hepatitis C, Inflammasome