cDNA Sequence AF251705 (AF251705) anticorps

N° du produit ABIN1108296

Détail du produit

Antigène: cDNA Sequence AF251705 (AF251705)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS)

Specificité: This antibody reacts with CD300d antigen.

Réactivité croisée (Details): Species reactivity (tested):Human (U937, Monocytes)

Purification: Protein A agarose

Immunogène: Ba/F3 transfectant expressing the human MAIR-II

Clone: TX45

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détail du antigène

Antigène: cDNA Sequence AF251705 (AF251705)

Autre désignation: MAIR-2 (Myeloid-Associated Immunoglobulin-Like Receptor) (AF251705 Produits)

Synonymes: anticorps CLM4, anticorps Cd300c, anticorps Cd300d, anticorps DIgR1, anticorps Igsf7, anticorps Lmir2, anticorps MAIR-II, anticorps CD300C molecule 2, anticorps Cd300c2

Sujet: Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).

ID gène: 140497

NCBI Accession: NP_598919

UniProt: Q7TSN2