CDK6 anticorps
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- Antigène Voir toutes CDK6 Anticorps
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CDK6 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody reacts specifically with Cdk6 kinase, which can substitute for Cdk4. Cdk6 is highly expressed in some lymphoid tumor and sarcoma cell lines (ML-1 and U-2-OS resp.). Positive staining is found in head and neck tumors.
- Purification
- Protein A affinity chromatography
- Immunogène
- Human recombinant full-length cdk6 polypeptide
- Clone
- DCS-83
- Isotype
- IgG1
- Top Product
- Discover our top product CDK6 Anticorps primaire
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- Indications d'application
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Immunohistochemistry on frozen sections and paraffin embedded tissue (after microwavetreatment): 1: 10 for 1 - 4 h at RT or overnight at 2-8C. Western Blot. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore in 1 mL dist. water.
- Buffer
- PBS, pH 7.4, containing 0.09 % NaN3, 0.5 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C up to one week or (in aliquots) at -20 °C for longer. Centrifuge vial before opening.
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- Antigène
- CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
- Autre désignation
- CDK6 (CDK6 Produits)
- Synonymes
- anticorps CDK6, anticorps PLSTIRE, anticorps 5830411I20, anticorps AI504062, anticorps Crk2, anticorps cyclin dependent kinase 6, anticorps cyclin-dependent kinase 6, anticorps CDK6, anticorps Cdk6
- Sujet
- Cdk6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE
- ID gène
- 1021
- NCBI Accession
- NP_001138778
- UniProt
- Q00534
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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