FLIP anticorps (AA 1-480)

N° du produit ABIN1169018

Cet anticorps Souris Monoclonal détecte spécifiquement FLIP dans WB, IHC et ICC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FLIP anticorps (AA 1-480) (ABIN1169018)

Antigène: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FLIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: NF6

Détail du produit anti-FLIP anticorps

Épitope: AA 1-480

Fonction: anti-FLIP (human), mAb (NF6)

Specificité: Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. This antibody recognizes an epitope in the N-terminal DED region (aa1-194).

Attributs du produit: Monoclonal Antibody. Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. This antibody recognizes an epitope in the N-terminal DED region (aa1-194). Isotype: Mouse IgG1. Clone: NF6. Applications: ICC, IHC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Immunogène: Recombinant human FLIP (aa 1-480).

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur FLIP

Antigène: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Autre désignation: FLIP

Sujet:

Alternate Names/Synonyms: I-FLICE, CLARP, CASPER, Usurpin, CASH, FLAME-1

Product Description: FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

UniProt: O15519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development