NAMPT anticorps

N° du produit ABIN1169028

Cité dans 7+ publications. Cet anticorps anti-NAMPT est un anticorps Monoclonal produit chez le Souris, détectant NAMPT dans WB, IHC, ELISA, IP, ICC et FACS. Convient pour Humain, Rat et Souris.

Aperçu rapide pour NAMPT anticorps (ABIN1169028)

Antigène: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NAMPT est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: OMNI379

Détail du produit anti-NAMPT anticorps

Specificité: Recognizes human, mouse and rat Nampt.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human Nampt (visfatin/PBEF).

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-NAMPT (ABIN1169028)

Audrito, Serra, Brusa, Mazzola, Arruga, Vaisitti, Coscia, Maffei, Rossi, Wang, Inghirami, Rizzi, Gaidano, Garcia, Wolberger, Raffaelli, Deaglio: "Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia." dans: Blood, Vol. 125, Issue 1, pp. 111-23, (2015) (PubMed).

Yoon, Yoshida, Johnson, Takikawa, Usui, Tobe, Nakagawa, Yoshino, Imai: "SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice." dans: Cell metabolism, Vol. 21, Issue 5, pp. 706-17, (2015) (PubMed).

Kover, Tong, Watkins, Clements, Stehno-Bittel, Novikova, Bittel, Kibiryeva, Stuhlsatz, Yan, Ye, Moore: "Expression and regulation of nampt in human islets." dans: PLoS ONE, Vol. 8, Issue 3, pp. e58767, (2013) (PubMed).

Garten, Petzold, Barnikol-Oettler, Körner, Thasler, Kratzsch, Kiess, Gebhardt: "Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes." dans: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 376-81, (2010) (PubMed).

Körner, Garten, Blüher, Tauscher, Kratzsch, Kiess: "Molecular characteristics of serum visfatin and differential detection by immunoassays." dans: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 12, pp. 4783-91, (2007) (PubMed).

Revollo, Körner, Mills, Satoh, Wang, Garten, Dasgupta, Sasaki, Wolberger, Townsend, Milbrandt, Kiess, Imai: "Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme." dans: Cell metabolism, Vol. 6, Issue 5, pp. 363-75, (2007) (PubMed).

Bae, Kim, Kim, Kim, Koo, Jang, Yun, Yoo, Bae: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." dans: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, (2006) (PubMed).

Détails sur NAMPT

Antigène: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Autre désignation: Nampt (Visfatin/PBEF)

Sujet: Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

UniProt: P43490