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FASL anticorps

FASL Reactivité: Humain WB, FACS, IP, Neut Hôte: Souris Monoclonal NOK-1 unconjugated
N° du produit ABIN1177002
  • Antigène Voir toutes FASL Anticorps
    FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
    Reactivité
    • 102
    • 52
    • 35
    • 18
    • 6
    • 4
    • 3
    • 2
    • 1
    Humain
    Hôte
    • 68
    • 35
    • 10
    • 5
    • 4
    • 3
    • 1
    Souris
    Clonalité
    • 75
    • 51
    Monoclonal
    Conjugué
    • 72
    • 14
    • 10
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FASL est non-conjugé
    Application
    • 82
    • 63
    • 28
    • 24
    • 22
    • 17
    • 13
    • 13
    • 10
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Neutralization (Neut)
    Marque
    BD Pharmingen™
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Stérilité
    0.2 μm filtered
    niveau d'endotoxine
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogène
    Mouse T lymphoma cells (L5178Y) expressing human FasL
    Clone
    NOK-1
    Isotype
    IgG1
    Top Product
    Discover our top product FASL Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Agent conservateur
    Azide free
    Stock
    4 °C
    Stockage commentaire
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Orlinick, Elkon, Chao: "Separate domains of the human fas ligand dictate self-association and receptor binding." dans: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32221-9, (1998) (PubMed).

    Oyaizu, Adachi, Hashimoto, McCloskey, Hosaka, Kayagaki, Yagita, Pahwa: "Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 5, pp. 2456-63, (1997) (PubMed).

    Sieg, Smith, Yildirim, Kaplan: "Fas ligand deficiency in HIV disease." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5860-5, (1997) (PubMed).

    Villunger, Egle, Marschitz, Kos, Böck, Ludwig, Geley, Kofler, Greil: "Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance." dans: Blood, Vol. 90, Issue 1, pp. 12-20, (1997) (PubMed).

    Walker, Saas, Dietrich: "Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 10, pp. 4521-4, (1997) (PubMed).

    Zavazava, Krönke: "Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes." dans: Nature medicine, Vol. 2, Issue 9, pp. 1005-10, (1996) (PubMed).

    Kayagaki, Kawasaki, Ebata, Ohmoto, Ikeda, Inoue, Yoshino, Okumura, Yagita: "Metalloproteinase-mediated release of human Fas ligand." dans: The Journal of experimental medicine, Vol. 182, Issue 6, pp. 1777-83, (1996) (PubMed).

    Tanaka, Suda, Takahashi, Nagata: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." dans: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, (1995) (PubMed).

    Takahashi, Tanaka, Brannan, Jenkins, Copeland, Suda, Nagata: "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand." dans: Cell, Vol. 76, Issue 6, pp. 969-76, (1994) (PubMed).

  • Antigène
    FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))
    Autre désignation
    CD178 (FASL Produits)
    Synonymes
    anticorps ALPS1B, anticorps APT1LG1, anticorps APTL, anticorps CD178, anticorps CD95-L, anticorps CD95L, anticorps FASL, anticorps TNFSF6, anticorps fasl, anticorps Fas-L, anticorps Faslg, anticorps Tnfsf6, anticorps gld, anticorps Apt1Lg1, anticorps Fasl, anticorps FASLG, anticorps zgc:162027, anticorps Fas ligand, anticorps Fas ligand L homeolog, anticorps Fas ligand (TNF superfamily, member 6), anticorps FASLG, anticorps faslg.L, anticorps Fasl, anticorps Faslg, anticorps faslg
    Sujet
    Fas (CD95, APO-1) is a 45 kDa cell surface protein that mediates apoptosis when cross-linked with agonistic anti-Fas antibodies or by Fas ligand (FasL, CD178). Fas belongs to the TNF (Tumor Necrosis Factor)/NGF (Nerve Growth Factor) receptor family, and is expressed in various tissues and cells including the thymus, liver, ovary and lung. CD178 (FasL), a member of the TNF cytokine family, induces apoptosis by binding to Fas, its cell-surface receptor. FasL may exist as either membrane bound or soluble forms and is expressed by activated T and NK cells. FasL may also be constitutively expressed in some immunologically privileged sites, e.g., eye and testis. Fas and FasL play an important role in the induction of apoptosis, and thus regulate a variety of immunological responses. The NOK-1 antibody clone has been reported to recognize human FasL, recognizing both the membrane bound (FasL) and soluble (sFasL) forms. It is reported that the epitope for NOK-1 has been mapped to the COOH-terminus of FasL, at the region implicated in Fas binding. FasL and sFasL have been reported to migrate at reduced molecular weights of 40 and 26 kDa, respectively. However, the molecular weights observed in a particular sample may vary according to FasL and sFasL glycosylation and breakdown patterns as described in the literature. The NOK-1 antibody clone is not recommended for the western blot application.
    Synonyms: Fas Ligand, CD95 Ligand
    Pathways
    Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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