Myeloperoxidase anticorps (PE)

N° du produit ABIN119049

Détail du produit anti-Myeloperoxidase anticorps (PE)

Antigène: Myeloperoxidase (MPO)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Myeloperoxidase est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Aucune reactivité croisée: Rat (Rattus)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein G

Immunogène: Human Myeloperoxiase Remarks: Spleen cells from immunised mice were fused with cells of the mouse X63 AG8-653 myeloma cell line.

Clone: 2C7

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Membrane permeabilisation is required for this application.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 1 mL distilled water

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative, 1 % BSA and 5 % sucrose as stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: This product is photosensitive and should be protected from light

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Références pour anticorps anti-Myeloperoxidase (PE) (ABIN119049)

Lau, Mollnau, Eiserich, Freeman, Daiber, Gehling, Brümmer, Rudolph, Münzel, Heitzer, Meinertz, Baldus: "Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 2, pp. 431-6, (2005) (PubMed).

Détails sur Myeloperoxidase

Antigène: Myeloperoxidase (MPO)

Autre désignation: Myeloperoxidase (MPO Produits)

Synonymes: anticorps mKIAA4033, anticorps MPO, anticorps LOC100335032, anticorps POX2', anticorps XPOX2', anticorps mpo, anticorps mpo-A, anticorps pmr-1, anticorps pmr1, anticorps pox2, anticorps xpox2, anticorps myeloperoxidase, anticorps myeloperoxidase L homeolog, anticorps MPO, anticorps Mpo, anticorps LOC100335032, anticorps mpo.L

Sujet: MPO is an important component of azurophilic granules in neutrophils. Myeloperoxidase is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. Native Myeloperoxidase is represented as a covalently bound tetrameric complex of two glycosylated alpha chains (MW 59 - 64 kDa) and two unglycosylated beta chains (MW 14 kDa) with total MW 150 kDa and theoretical pI 9.2. Traditionally Myeloperoxidase was considered as a main target of anti-neutrophil cytoplasm antibodies (ANCA), the serological markers for certain systemic vasculities e.g. periarteriitis nodosa, microscopic polyarteriitis and pulmonary eosinophilic granulomatosis (Churg-Strauss syndrome). Low to moderate anti-Myeloperoxidase autoantibody levels are also reported in rheumatoid arthritis. Recently it was shown that Myeloperoxidase participates in the initiation and progression of cardiovascular disease. It possesses potent proinflammatory properties and may contribute directly to tissue injury. Now Myeloperoxidase is under consideration as one of the most promising cardiac markers.Synonyms: MPO

ID gène: 9606

UniProt: P05164

Pathways: Chromatin Binding