CDK6 anticorps

N° du produit ABIN119189

L’anticorps anti-CDK6 Monoclonal Souris est utilisé pour la détection de CDK6 dans des échantillons de Humain. Il a été validé pour WB, IP et IHC (fro).

Aperçu rapide pour CDK6 anticorps (ABIN119189)

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK6 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: DCS-83-1

Détail du produit anti-CDK6 anticorps

Specificité: This antibody recognises Cyclin Dependent Kinase 6 (Cdk6), a 40 kDa protein which plays an important role in the progression of G1 to S.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogène: Recombinant CDK6 protein.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections. Recommended positive control tissue: U-2-OS sarcoma cell line.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CDK6

Antigène: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Autre désignation: CDK6

Sujet: Cdk6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE

ID gène: 1021

NCBI Accession: NP_001138778

UniProt: Q00534

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases