ITGB1 anticorps (FITC)

N° du produit ABIN125998

Cet anticorps Souris Monoclonal détecte spécifiquement ITGB1 dans FACS. Il présente une réactivité envers Humain, Porc et Chien et a été mentionné dans 2+ publications.

Aperçu rapide pour ITGB1 anticorps (FITC) (ABIN125998)

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Reactivité: Humain, Porc, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ITGB1 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: MEM-101A

Détail du produit anti-ITGB1 anticorps (FITC)

Immunogène: Raji Burkitt's lymphoma cell line

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry: Use 20 μL of ready-to-use antibody to label 100 μL of whole blood or 10^6 cells in a suspension.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody (undiluted) in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light.
Shelf Life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-ITGB1 (FITC) (ABIN125998)

Símová, Klíma, Cermak, Sourková, Andera: "Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane." dans: Apoptosis : an international journal on programmed cell death, Vol. 13, Issue 3, pp. 423-36, (2008) (PubMed).

Millán, Cerny, Horejsi, Alonso: "CD4 segregates into specific detergent-resistant T-cell membrane microdomains." dans: Tissue antigens, Vol. 53, Issue 1, pp. 33-40, (1999) (PubMed).

Détails sur ITGB1

Antigène: ITGB1 (Integrin beta 1 (ITGB1))

Autre désignation: CD29 / Integrin beta-1

Sujet: CD29 (b1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 dibberent a chains (a1-a6, CD49a-f) determining the binding properties of b1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most b1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of b1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a b1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1b.Synonyms: FNRB, Fibronectin receptor subunit beta, ITGB1, Integrin VLA-4 subunit beta, MDF2, MSK12

UniProt: P05556

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome