The antibody detects both 43 and 60 kDa isoforms, corresponding to the apparent molecular mass of MAPKAPK-2 on SDS-PAGE immunoblots. These 43 kDa and 60 kDa bands can be specifically inhibited by the relevant peptide.
MAPKAPK2
Reactivité: Humain
IHC (p), DB
Hôte: Lapin
Polyclonal
RB05555
unconjugated
Indications d'application
Western Blot: 0.5-4 μg/mL. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps mapkapk2, anticorps wu:fb30e10, anticorps wu:fc56c10, anticorps wu:fi03a01, anticorps MGC78852, anticorps MAPKAPK2, anticorps AA960234, anticorps MAPKAP-K2, anticorps MK-2, anticorps MK2, anticorps Rps6kc1, anticorps mitogen-activated protein kinase-activated protein kinase 2a, anticorps mitogen-activated protein kinase-activated protein kinase 2 L homeolog, anticorps mitogen-activated protein kinase-activated protein kinase 2, anticorps MAP kinase-activated protein kinase 2, anticorps mapkapk2a, anticorps mapkapk2.L, anticorps MAPKAPK2, anticorps Mapkapk2
Sujet
MAP kinase-activated protein kinase-2 (MAPKAPK-2), also known as p45 hsp27 kinase, is a 45-54 kDa serine-threonine protein kinase that contains a proline rich sequence and two putative SH3-binding sites. MAPKAPK-2 is activated in response to stress, IL-1 and TNF, possibly catalyzed by p38/Hog-dependent phosphorylation. One of the major substrates of MAPKAPK-2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. Two isoforms are produced due to alternative splicing of the same gene which differ in their C-terminals.Synonyms: MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MAPKAPK2, MK2