NCAPH anticorps (AA 440-457)

N° du produit ABIN129615

Détail du produit anti-NCAPH anticorps

Antigène: NCAPH (Non-SMC Condensin I Complex, Subunit H (NCAPH))

Épitope: AA 440-457

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCAPH est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 440-457 of Human BRRN-1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 83 kDa in size corresponding to human BRRN1 by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.93 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur NCAPH

Antigène: NCAPH (Non-SMC Condensin I Complex, Subunit H (NCAPH))

Autre désignation: BRRN-1 (NCAPH Produits)

Synonymes: anticorps NCAPH, anticorps si:dkeyp-86b9.4, anticorps zgc:158618, anticorps BRRN1, anticorps CAP-H, anticorps brrn1, anticorps cap-h, anticorps A730011O11Rik, anticorps Brrn1, anticorps HCAP-H, anticorps mKIAA0074, anticorps non-SMC condensin I complex subunit H, anticorps non-SMC condensin I complex, subunit H, anticorps condensin complex subunit 2, anticorps non-SMC condensin I complex subunit H S homeolog, anticorps NCAPH, anticorps ncaph, anticorps LOC708975, anticorps ncaph.S, anticorps Ncaph

Sujet: BRNN1, also called Barren, Condensin subunit 2, Barren homolog protein 1, Chromosome-associated protein H, hCAP-H, and XCAP-H homolog, is encoded by a gene that is a member of the barr gene family.  Brnn1 is the regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.   The condensin complex contains the SMC2L1 and SMC4L1 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.   BRRN1 has both a nuclear and cytoplasmic localization.  In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2 leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. BRRN1 is widely expressed at low level in most proliferating cells.  CDC2 phosphorylates BRRN1.  Its phosphorylation, as well as that of CNAP1 and CAPG subunits, activates the condensin complex and is required for chromosome condensation.
Synonyms: Barren Drosophila Homolog of 1 antibody, Barren homolog protein 1 antibody, BRRN antibody, CAP H antibody, CAPH antibody, Chromosome associated protein H antibody, Condensin complex subunit 2 antibody, Condensin subunit 2 antibody

ID gène: 23397

UniProt: Q15003