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GZMB anticorps

GZMB Reactivité: Humain, Non-Human Primate FACS Hôte: Souris Monoclonal CLB-GB11 unconjugated
N° du produit ABIN1302451
  • Antigène Voir toutes GZMB Anticorps
    GZMB (Granzyme B (GZMB))
    Reactivité
    • 124
    • 53
    • 25
    • 10
    • 3
    • 2
    • 1
    • 1
    Humain, Non-Human Primate
    Hôte
    • 80
    • 47
    • 2
    Souris
    Clonalité
    • 76
    • 53
    Monoclonal
    Conjugué
    • 80
    • 11
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GZMB est non-conjugé
    Application
    • 72
    • 42
    • 39
    • 37
    • 19
    • 18
    • 18
    • 14
    • 13
    • 10
    • 9
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human NK cell line YT-INDY-derived granzyme B
    Clone
    CLB-GB11
    Isotype
    IgG1
    Top Product
    Discover our top product GZMB Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Rissoan, Duhen, Bridon, Bendriss-Vermare, Péronne, de Saint Vis, Brière, Bates: "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells." dans: Blood, Vol. 100, Issue 9, pp. 3295-303, (2002) (PubMed).

    Tak, Spaeny-Dekking, Kraan, Breedveld, Froelich, Hack: "The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)." dans: Clinical and experimental immunology, Vol. 116, Issue 2, pp. 366-70, (1999) (PubMed).

    Spaeny-Dekking, Hanna, Wolbink, Wever, Kummer, Kummer, Swaak, Middeldorp, Huisman, Froelich, Hack: "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3610-6, (1998) (PubMed).

  • Antigène
    GZMB (Granzyme B (GZMB))
    Autre désignation
    Granzyme B (GZMB Produits)
    Synonymes
    anticorps CCPI, anticorps CGL-1, anticorps CGL1, anticorps CSP-B, anticorps CSPB, anticorps CTLA1, anticorps CTSGL1, anticorps HLP, anticorps SECT, anticorps granzyme B, anticorps GZMB
    Sujet
    Granzyme B,Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.,GZMB, HLP, CTLA1, SECT
    ID gène
    3002
    UniProt
    P10144
    Pathways
    Apoptose, Caspase Cascade in Apoptosis
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