CD36 anticorps (PE)

N° du produit ABIN1303148

Détail du produit anti-CD36 anticorps (PE)

Antigène: CD36

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD36 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The mouse monoclonal antibody CB38 (NL07) recognizes an extracellular epitope of CD36 (GPIIIb), a 85-113 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: living human myeloid cells

Clone: CB38

Isotype: IgM kappa

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Reconstitution: No reconstitution is necessary.

Buffer: Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.
Avoid prolonged exposure to light.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-CD36 (PE) (ABIN1303148)

Moniuszko, Kowal, Rusak, Pietruczuk, Dabrowska, Bodzenta-Lukaszyk: "Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants." dans: Clinical and vaccine immunology : CVI, Vol. 13, Issue 6, pp. 704-7, (2006) (PubMed).

McKenna, Washington, Aquino, Picker, Kroft: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry." dans: Blood, Vol. 98, Issue 8, pp. 2498-507, (2001) (PubMed).

Hoffmann, deCathelineau, Ogden, Leverrier, Bratton, Daleke, Ridley, Fadok, Henson: "Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells." dans: The Journal of cell biology, Vol. 155, Issue 4, pp. 649-59, (2001) (PubMed).

Matasić, Dietz, Vuk-Pavlović: "Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells." dans: Journal of leukocyte biology, Vol. 66, Issue 6, pp. 909-14, (2000) (PubMed).

Fadok, Warner, Bratton, Henson: "CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6250-7, (1998) (PubMed).

Alessio, Greco, Primo, Ghigo, Bosia, Tandon, Ockenhouse, Jamieson, Malavasi: "Platelet activation and inhibition of malarial cytoadherence by the anti-CD36 IgM monoclonal antibody NL07." dans: Blood, Vol. 82, Issue 12, pp. 3637-47, (1994) (PubMed).

Alessio, Roggero, Bussolino, Saitta, Malavasi: "Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule)." dans: Current studies in hematology and blood transfusion, Issue 58, pp. 182-6, (1992) (PubMed).

Alessio, Ghigo, Garbarino, Geuna, Malavasi: "Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07." dans: Cellular immunology, Vol. 137, Issue 2, pp. 487-500, (1991) (PubMed).

Détails sur CD36

Antigène: CD36

Autre désignation: CD36 (CD36 Produits)

Synonymes: anticorps BDPLT10, anticorps CHDS7, anticorps FAT, anticorps GP3B, anticorps GP4, anticorps GPIV, anticorps PASIV, anticorps SCARB3, anticorps Fat, anticorps Scarb3, anticorps GPIIIB, anticorps PAS-4, anticorps zgc:92513, anticorps CD36 molecule, anticorps CD36 molecule (thrombospondin receptor), anticorps CD36, anticorps Cd36, anticorps cd36

Sujet: CD36 Molecule,CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.,GPIIIb, GPIV, PAS-4, FAT, Thrombospondin receptor, PASIV

ID gène: 948

UniProt: P16671

Pathways: Signalisation TLR, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins