Sca-1/Ly-6A/E anticorps

N° du produit ABIN133910

Détail du produit anti-Sca-1/Ly-6A/E anticorps

Antigène: Sca-1/Ly-6A/E (Ly6a) (Lymphocyte Antigen 6 Complex, Locus A (Ly6a))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Sca-1/Ly-6A/E est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Mouse Sca-1

Purification: Purified from ascitic fluid via Protein G Chromatography

Isotype: IgG2b

Information d'application

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/ml

Buffer: Purified Ig buffered in PBS and 0.02% NaN3 (Purified from ascites via Protein G Chromatography).

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-Sca-1/Ly-6A/E (ABIN133910)

Sin, Puccini, Huang, Konstandin, Gilbert, Sussman, Gottlieb, Feuer: "The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development." dans: PLoS pathogens, Vol. 10, Issue 7, pp. e1004249, (2015) (PubMed).

Détails sur Sca-1/Ly-6A/E

Antigène: Sca-1/Ly-6A/E (Ly6a) (Lymphocyte Antigen 6 Complex, Locus A (Ly6a))

Autre désignation: Sca-1 (Ly6a Produits)

Synonymes: anticorps Ly-6A.2, anticorps Ly-6A/E, anticorps Ly-6E.1, anticorps Sca-1, anticorps Sca1, anticorps TAP, anticorps lymphocyte antigen 6 complex, locus A, anticorps Ly6a

Sujet: Monoclonal antibody recognizes Sca-1 (Ly-6A.2/6E.1), a cell surface antigen used in the identification of hematopoietic stem cells. It is a member of the Ly-6 antigen family. The Thy-1 lo , Lin (lineage-negative, not expressing B220, Gr-1, Mac-1, CD4 or CD8), Sca-1 population of bone marrow cells are highly purified, perhaps homogenous, pluripotent stem cells. This antigen is also present on various other tissues. Specific staining of the parenchymal cells can be demonstrated in thymus, spleen and kidney where as only vasculature reacts with anti-Sca- 1 in brain, heart and liver (and possibly in lung). Also, Sca-1 is a T cell activation antigen, as surface expression of the antigen increases upon Con A activation of T lymphocytes. Sca-1 appears to have a molecular mass of 8 kDa under non-reducing conditions and 18 kDa under reducing conditions, indicating the presence of intra-chain disulfide bonds.

Pathways: Sensory Perception of Sound, Activated T Cell Proliferation