CD11b anticorps

N° du produit ABIN135135

Cet anticorps anti-CD11b est un anticorps Rat Monoclonal détectant CD11b dans FACS. Adapté pour Souris. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour CD11b anticorps (ABIN135135)

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: Flow Cytometry (FACS)

Clone: M1-70

Détail du produit anti-CD11b anticorps

Specificité: Mouse/Human/Rhesus/Baboon/Rabbit CD11b, Mr 170 kDa

Attributs du produit: Rat Anti-Mouse CD11b-UNLB

Purification: Purified

Immunogène: C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes

Isotype: IgG2b

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, and AF488 conjugates 1 g/106 cells PE, APC, SPRD, CY5, PE/CY7, APC/CY7, PACBLU, AF647 and AF700 0.3 g/106 cells conjugates For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

In vitro and in vivo blocking

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-CD11b (ABIN135135)

Zempo, Suzuki, Ogawa, Watanabe, Fujiu, Manabe, Conway, Taniyama, Morishita, Hirata, Isobe, Nagai: "Influence of periostin-positive cell-specific Klf5 deletion on aortic thickening in DOCA-salt hypertensive mice." dans: Hypertension research : official journal of the Japanese Society of Hypertension, Vol. 39, Issue 11, pp. 764-768, (2017) (PubMed).

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: CD11b

Sujet: CD11b, the integrin M subunit, combines with CD18, the integrin 2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation