CD11b anticorps

N° du produit ABIN135141

Cet anticorps anti-CD11b Monoclonal Rat (Clone M1-70) (ABIN135141) détecte spécifiquement CD11b dans FACS, IP, IHC (fro), ICC, IHC (p) et BR. L’anticorps est réactif avec des échantillons de Humain, Souris, Lapin, Babouin et Macaque rhésus.

Aperçu rapide pour CD11b anticorps (ABIN135141)

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivité: Humain, Souris, Lapin, Babouin, Macaque rhésus

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD11b est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Reagent (BR)

Clone: M1-70

Détail du produit anti-CD11b anticorps

Fonction: Rat Anti-Mouse CD11b-LE/AF

Specificité: Mouse/Human/Rhesus/Baboon/Rabbit CD11b, Mr 170 kDa

Attributs du produit: Low Endotoxin/Azide Free Anti-Mouse CD11b antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.

niveau d'endotoxine: Low Endotoxin

Immunogène: C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur CD11b

Antigène: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Autre désignation: CD11b

Sujet: CD11b, the integrin M subunit, combines with CD18, the integrin 2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.

ID gène: 16409, 3684, 714832

UniProt: P05555

Pathways: Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation