TNFRSF8 anticorps

N° du produit ABIN135189

Détail du produit anti-TNFRSF8 anticorps

Antigène: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFRSF8 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Mouse CD30, Mr 105-120 kDa

Attributs du produit: Hamster Anti-Mouse CD30-UNLB

Purification: Purified

Immunogène: Mouse CD30-mouse IgG1 fusion protein

Clone: MCD30-1

Isotype: IgG

Information d'application

Indications d'application:

• Applications: FC - Quality tested , Stim - Reported in literature , Costim - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry Purified (UNLB) antibody 3 g/106 cells FITC and BIOT conjugates 3 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Commentaires:

In vitro functional studies

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-TNFRSF8 (ABIN135189)

Gur-Cohen, Itkin, Chakrabarty, Graf, Kollet, Ludin, Golan, Kalinkovich, Ledergor, Wong, Niemeyer, Porat, Erez, Sagi, Esmon, Ruf, Lapidot: "PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells." dans: Nature medicine, Vol. 21, Issue 11, pp. 1307-17, (2016) (PubMed).

Détails sur TNFRSF8

Antigène: TNFRSF8 (Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))

Autre désignation: CD30 (TNFRSF8 Produits)

Synonymes: anticorps CD30, anticorps D1S166E, anticorps Ki-1, anticorps Cd30, anticorps Ki, anticorps TNFRSF8, anticorps TNF receptor superfamily member 8, anticorps tumor necrosis factor receptor superfamily, member 8, anticorps TNFRSF8, anticorps Tnfrsf8

Sujet: CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus, and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.