CELSR2 anticorps (AA 201-300)

N° du produit ABIN1385874

Détail du produit anti-CELSR2 anticorps

Antigène: CELSR2 (Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2))

Épitope: AA 201-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CELSR2 est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CELSR2

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur CELSR2

Antigène: CELSR2 (Cadherin EGF LAG Seven Pass G-Type Receptor 2 (CELSR2))

Autre désignation: CELSR2 (CELSR2 Produits)

Synonymes: anticorps CDHF10, anticorps EGFL2, anticorps Flamingo1, anticorps MEGF3, anticorps Megf3, anticorps flamingo, anticorps mKIAA0279, anticorps mfmi1, anticorps cadherin EGF LAG seven-pass G-type receptor 2, anticorps cadherin, EGF LAG seven-pass G-type receptor 2, anticorps CELSR2, anticorps Celsr2

Sujet:

Synonyms: Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog, Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, CDHF10, CELR2_HUMAN, Celsr2, EGF like domain multiple 2, EGF-like protein 2, EGFL2, epidermal growth factor like 2, Epidermal growth factor-like protein 2, Flamingo homolog 3, Flamingo1, KIAA0279, MEGF3, Multiple EGF-like domains protein 3, Multiple epidermal growth factor-like domains protein 3.

Background: Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.