PPP1R9A anticorps (AA 115-165)

N° du produit ABIN1387768

Détail du produit anti-PPP1R9A anticorps

Antigène: PPP1R9A (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A))

Épitope: AA 115-165

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP1R9A est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Neurabin 1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PPP1R9A

Antigène: PPP1R9A (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 9A (PPP1R9A))

Autre désignation: Neurabin 1/PPP1R9A (PPP1R9A Produits)

Synonymes: anticorps 2810430P21Rik, anticorps 4930518N04Rik, anticorps 5330407E15, anticorps A230094E16Rik, anticorps BB181831, anticorps NRB, anticorps mKIAA1222, anticorps neurabin-I, anticorps NRB1, anticorps NRBI, anticorps Neurabin-I, anticorps Neb1, anticorps protein phosphatase 1, regulatory (inhibitor) subunit 9A, anticorps protein phosphatase 1 regulatory subunit 9A, anticorps protein phosphatase 1, regulatory subunit 9A, anticorps Ppp1r9a, anticorps PPP1R9A

Sujet:

Synonyms: FLJ20068, KIAA1222, NEB1_HUMAN, Neurabin I, Neurabin-1, Neurabin-I, Neurabin1, Neurabin-1, NeurabinI, Neurabin1, Neural tissue specic F actin binding protein I, Neural tissue-specic F-actin-binding protein I, NRB 1, NRB I, NRB1, NRBI, PPP1R9A, Protein phosphatase 1 regulatory inhibitor subunit 9A, Protein phosphatase 1 regulatory subunit 9A.

Background: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons, it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence, mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).