FARP2 anticorps (AA 601-700) (Biotin)

N° du produit ABIN1391401

Détail du produit anti-FARP2 anticorps (Biotin)

Antigène: FARP2 (FERM, RhoGEF and Pleckstrin Domain Protein 2 (FARP2))

Épitope: AA 601-700

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FARP2 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Human,Mouse,Rat,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human FARP2

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur FARP2

Antigène: FARP2 (FERM, RhoGEF and Pleckstrin Domain Protein 2 (FARP2))

Autre désignation: FARP2 (FARP2 Produits)

Synonymes: anticorps FARP2, anticorps wu:fc23d05, anticorps wu:fp25d09, anticorps MGC131000, anticorps FIR, anticorps FRG, anticorps PLEKHC3, anticorps AI465173, anticorps BC009153, anticorps D030026M03Rik, anticorps Fir, anticorps mKIAA0793, anticorps FERM, ARH/RhoGEF and pleckstrin domain protein 2, anticorps FERM, RhoGEF and pleckstrin domain protein 2, anticorps FERM, ARH/RhoGEF and pleckstrin domain protein 2 L homeolog, anticorps FARP2, anticorps farp2, anticorps farp2.L, anticorps Farp2

Sujet:

Synonyms: FARP 2, FERM, FGD1 related Cdc42 GEF, FIR, FRG, KIAA0793, PLEKHC3, RhoGEF and pleckstrin domain protein 2, FARP2_HUMAN.

Background: FARP2 is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.